C
Carlos Bustamante
Researcher at Stanford University
Publications - 799
Citations - 122303
Carlos Bustamante is an academic researcher from Stanford University. The author has contributed to research in topics: Population & DNA. The author has an hindex of 161, co-authored 770 publications receiving 106053 citations. Previous affiliations of Carlos Bustamante include Lawrence Berkeley National Laboratory & University of California.
Papers
More filters
of the effect of template tension on T7 DNA polymerase activity
TL;DR: In this paper, a single-molecule assay based on the differential elasticity of single-stranded and doublestranded DNA was used to show that mechanical force is generated during the rate-limiting step and that the motor can work against a maximum template tension of ∼34
Journal ArticleDOI
Molecular evidence for a single evolutionary origin of domesticated rice
Jeanmaire Molina,Martin Sikora,Nandita R. Garud,Jonathan M. Flowers,Samara Rubinstein,Andy Reynolds,Pu Huang,Scott A. Jackson,Barbara A. Schaal,Carlos Bustamante,Adam R. Boyko,Michael D. Purugganan +11 more
TL;DR: Demographic modeling based on SNP data and a diffusion-based approach provide the strongest support for a single domestication origin of rice, and Bayesian phylogenetic analyses implementing the multispecies coalescent and using previously published phylogenetic sequence datasets also point to a single origin of Asian domesticated rice.
Journal ArticleDOI
Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
Brenna M. Henn,Christopher R. Gignoux,Matthew J. Jobin,Julie M. Granka,John Michael Macpherson,Jeffrey M. Kidd,Laura Rodríguez-Botigué,Sohini Ramachandran,Lawrence Hon,Abra Brisbin,Alice A. Lin,Peter A. Underhill,David Comas,Kenneth K. Kidd,Paul Norman,Peter Parham,Carlos Bustamante,Joanna L. Mountain,Marcus W. Feldman +18 more
TL;DR: It is found that African hunter-gatherer populations today remain highly differentiated, encompassing major components of variation that are not found in other African populations, and tend to have the lowest levels of genome-wide linkage disequilibrium among 27 African populations.
Journal ArticleDOI
Genome-wide patterns of population structure and admixture among Hispanic/Latino populations
Katarzyna Bryc,Christopher Velez,Tatiana M. Karafet,Andrés Moreno-Estrada,Andrés Moreno-Estrada,Andrew R. Reynolds,Adam Auton,Adam Auton,Michael F. Hammer,Carlos Bustamante,Carlos Bustamante,Harry Ostrer +11 more
TL;DR: The results suggest future genome-wide association scans in Hispanic/Latino populations may require correction for local genomic ancestry at a subcontinental scale when associating differences in the genome with disease risk, progression, and drug efficacy, as well as for admixture mapping.
Journal ArticleDOI
DNA overwinds when stretched
Jeff Gore,Zev Bryant,Zev Bryant,Marcelo Nollmann,Mai U. Le,Nicholas R. Cozzarelli,Carlos Bustamante +6 more
TL;DR: It is shown that for small distortions, contrary to intuition, DNA overwinds under tension, reaching a maximum twist at a tension of ∼30 pN, and the observed twist–stretch coupling predicts that DNA should also lengthen when overwound under constant tension, an effect that is quantitatively confirmed.