Carlos Bustamante

TL;DR: In this paper, the authors proposed the inclusion of a greater diversity of individuals in immunogenomics studies, which will substantially enhance our understanding of human immunology and improve the ability to identify variation in human adaptive immune responses across populations.

TL;DR: Atomic force microscopy is used to visualize the initial interaction of transposase protein with P element DNA and shows that the P element transpos enzyme exists as a pre-formed tetramer that initially binds to either one of the two P element ends in the absence of GTP prior to synapsis.

TL;DR: Puerto Rican ethnicity and mixed origin were associated with degree of atopy within US Latino children with asthma and local environment variation, represented by site, was associated withdegree of sensitization.

TL;DR: The ability to manipulate and probe individual molecules or molecular complexes has led to a new, more refined understanding of the mechanical properties of the fundamental building blocks of the cell and of the mechanism by which molecular machines function.

TL;DR: It is shown that catalysis does not increase the diffusion of alkaline phosphatase (ALP) at the single-molecule level, in sharp contrast to the ∼20% enhancement seen in parallel FCS experiments using p-nitrophenyl phosphate (pNPP) as substrate, and it is established that pNPP-induced dye blinking at the ∼10-ms timescale is responsible for the apparent diffusion enhancements seen in FCS.