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Carlos Bustamante
Researcher at Stanford University
Publications - 799
Citations - 122303
Carlos Bustamante is an academic researcher from Stanford University. The author has contributed to research in topics: Population & DNA. The author has an hindex of 161, co-authored 770 publications receiving 106053 citations. Previous affiliations of Carlos Bustamante include Lawrence Berkeley National Laboratory & University of California.
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Journal ArticleDOI
Transcriptional activation via DNA-looping: visualization of intermediates in the activation pathway of E. coli RNA polymerase x sigma 54 holoenzyme by scanning force microscopy.
TL;DR: Scanning force microscopy has been used to study transcriptional activation of Escherichia coli RNA polymerase x sigma 54 at the glnA promoter by the constitutive mutant NtrC(D54E,S160F) of the NTrC Protein (nitrogen regulatory protein C).
Posted Content
Reconstructing Native American Migrations from Whole-genome and Whole-exome Data
Simon Gravel,Fouad Zakharia,Andrés Moreno-Estrada,Jake K. Byrnes,Marina Muzzio,Juan L. Rodriguez-Flores,Eimear E. Kenny,Christopher R. Gignoux,Brian K. Maples,Wilfried Guiblet,Julie Dutil,Marc Via,Karla Sandoval,Gabriel Bedoya,Taras K. Oleksyk,Andres Ruiz-Linares,Esteban G. Burchard,Juan Carlos Martínez-Cruzado,Carlos Bustamante +18 more
TL;DR: The genomic contributions of African, European, and especially Native American ancestry to these populations are explored and identity-by-descent (IBD) and ancestry tract length are compared to find evidence for relatedness among European founders to the three populations.
Journal ArticleDOI
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.
Frederick E. Dewey,Rong Chen,Sergio Cordero,Kelly E. Ormond,Colleen Caleshu,Konrad J. Karczewski,Michelle Whirl-Carrillo,Matthew T. Wheeler,Joel T. Dudley,Jake K. Byrnes,Omar E. Cornejo,Joshua W. Knowles,Mark Woon,Katrin Sangkuhl,Li Gong,Caroline F. Thorn,Joan M. Hebert,Emidio Capriotti,Sean P. David,Aleksandra Pavlovic,Anne West,Joseph V. Thakuria,Madeleine Ball,Alexander Wait Zaranek,Heidi L. Rehm,George M. Church,John West,Carlos Bustamante,Michael Snyder,Russ B. Altman,Teri E. Klein,Atul J. Butte,Euan A. Ashley +32 more
TL;DR: A novel synthetic human reference sequence is developed that is ethnically concordant and used for the analysis of genomes from a nuclear family with history of familial thrombophilia, demonstrating that the use of the major allele reference sequence results in improved genotype accuracy for disease-associated variant loci.
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Natural selection on the olfactory receptor gene family in humans and chimpanzees
TL;DR: In both humans and chimpanzees, OR pseudogenes seem to evolve neutrally, whereas, in humans, there is suggestive evidence for positive selection acting on intact OR genes, which is likely due to differences in lifestyle, between humans and great apes, that have led to distinct sensory needs.
Journal ArticleDOI
High-throughput single nucleotide polymorphism genotyping for breeding applications in rice using the BeadXpress platform
Michael J. Thomson,Keyan Zhao,Keyan Zhao,Mark G. Wright,Kenneth L. McNally,Jessica Rey,Chih-Wei Tung,Andrew R. Reynolds,Brian E. Scheffler,Georgia C. Eizenga,Anna M. McClung,HyunJung Kim,Abdelbagi M. Ismail,Marjorie de Ocampo,Chromewell Mojica,Ma. Ymber Reveche,Christine Jade Dilla-Ermita,Ramil Mauleon,Hei Leung,Carlos Bustamante,Carlos Bustamante,Susan R. McCouch +21 more
TL;DR: Pilot studies were successfully performed for diversity analysis, QTL mapping, marker-assisted backcrossing, and developing specialized genetic stocks, demonstrating that 384-plex SNP genotyping on the BeadXpress platform is a robust and efficient method for marker genotypesing in rice.