C
Carlos Bustamante
Researcher at Stanford University
Publications - 799
Citations - 122303
Carlos Bustamante is an academic researcher from Stanford University. The author has contributed to research in topics: Population & DNA. The author has an hindex of 161, co-authored 770 publications receiving 106053 citations. Previous affiliations of Carlos Bustamante include Lawrence Berkeley National Laboratory & University of California.
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Posted ContentDOI
A DNA translocase operates by cycling between planar and lock-washer structures
TL;DR: A helical inchworm translocation mechanism is proposed in which the motor increasingly adopts a lock-washer structure during the ATP loading dwell and successively regains its planar form with each power stroke during the burst.
Peer ReviewDOI
Author response: Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism
Manchuta Dangkulwanich,Toyotaka Ishibashi,Toyotaka Ishibashi,Shixin Liu,Maria L. Kireeva,Lucyna Lubkowska,Mikhail Kashlev,Carlos Bustamante +7 more
Journal ArticleDOI
A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery
Liang Meng Wee,Alexander B. Tong,Alfredo Jose Florez Ariza,Cristhian Cañari-Chumpitaz,Patricia Grob,Eva Nogales,Carlos Bustamante +6 more
TL;DR: In this article , the ribosome can prevent pausing and termination of RNA polymerase (RNAP) and double the overall transcription rate at the expense of fidelity, while coupling increases the pause-free velocity of the polymerase and explains the majority of the effects of coupling.
Posted ContentDOI
High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier
Zhijie Chen,Ronen Gabizon,Carlos Bustamante,Tingting Yao,Antony Lee,César Díaz-Celis,Elena F. Koslover,Aidan I. Brown,Aixin Song +8 more
TL;DR: Topographic and transcriptional maps of canonical, H2A.Z, and monoubiquitinated H2B (uH2B) nucleosomes are obtained at near base-pair resolution and accuracy and a unified mechanical model links position-dependent dwell times of Pol II on the nucleosome with energetics of the barrier.