Carlos Bustamante

TL;DR: An absolute requirement for the globular domain of the linker histones and a structural redundancy of the tails of linkerhistones and of histone H3 in determining conformational stability is demonstrated.

TL;DR: In this paper, the authors derived analytical expressions for the circular intensity differential of scattering (CIDS) as a function of the helix parameters and the wavelength of light and showed that a sufficient condition for differential scattering for right and left circularly polarized light is the existence of an asymmetric polarizability.

TL;DR: It is found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans, a fact that can be interpreted as a sign of Ne andertal admixture.

TL;DR: The kinetic mechanism of Escherichia coli RNAP is probed by studying the force-velocity behavior of individual RNAP complexes at temperatures between 7 and 45 degrees C using optical tweezers, finding that arrest could play a regulatory role in vivo, possibly through interactions with specific elongation factors.

TL;DR: The strong mechanical stability of even a minimal kissing complex indicates the importance of such loop–loop interactions in initiating and stabilizing RNA dimers in retroviruses.