Carlos Bustamante

TL;DR: The fetal genetic contribution to PTB is unlikely due to single common genetic variant, but could be explained by interactions of multiple common variants, or of rare variants affected by environmental influences, all not detectable using a GWAS alone.

TL;DR: Identification of the mutations responsible for these two early-onset retinal degenerations provides new large animal models for comparative disease studies and evaluation of potential therapeutic approaches for the homologous human diseases.

TL;DR: MMasked preparations of DNA deposited on platinum/carbon-coated mica and highly oriented pyrolytic graphite were examined with a tunneling current 1000 times lower than the usual nanoamps and the tip apparently displaces molecules adsorbed to graphite to preclude imaging whereas more stably bound DNA on Platinum/ carbon-coating mica appears in reversed contrast.

TL;DR: The utility of a theoretical framework, recently formulated in which a generalized friction coefficient quantifies the energetic efficiency in nonequilibrium processes, is demonstrated by rapidly unfolding and folding single DNA hairpins by designing efficient driving processes (“protocols”).

TL;DR: The implications of population structure for the distribution and discovery of disease-causing genetic variants, in the light of the imminent availability of sequencing data for a multitude of diverse human genomes, are discussed.