C
Carlos Bustamante
Researcher at Stanford University
Publications - 799
Citations - 122303
Carlos Bustamante is an academic researcher from Stanford University. The author has contributed to research in topics: Population & DNA. The author has an hindex of 161, co-authored 770 publications receiving 106053 citations. Previous affiliations of Carlos Bustamante include Lawrence Berkeley National Laboratory & University of California.
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Journal ArticleDOI
Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.
Rong Chen,Erik Corona,Erik Corona,Martin Sikora,Joel T. Dudley,Joel T. Dudley,Alexander A. Morgan,Alexander A. Morgan,Andrés Moreno-Estrada,Geoffrey B. Nilsen,David Ruau,David Ruau,Stephen E. Lincoln,Carlos Bustamante,Atul J. Butte,Atul J. Butte +15 more
TL;DR: Type 2 diabetes (T2D) demonstrated extreme directional differentiation of risk allele frequencies across human populations, compared with null distributions of European-frequency matched control genomic alleles and risk alleles for other diseases, and these patterns contribute to disparities in predicted genetic risk.
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Scanning force microscopy of nucleic acids and nucleoprotein assemblies
TL;DR: In this article, the main technical advances of the past year, which often took place in connection with the imaging of nucleic acids and nucleoprotein assemblies, are reviewed and potential solutions to present technical limitations and promising new developments now underway are also discussed.
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Probing the Mechanical Folding Kinetics of TAR RNA by Hopping, Force-Jump, and Force-Ramp Methods
TL;DR: The force-jump method is developed, which finds that folding of RNA hairpins can be more complex than a simple single-step reaction, and that application of several methods can improve understanding of reaction mechanisms.
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Substrate interactions and promiscuity in a viral DNA packaging motor
K. Aathavan,Adam T. Politzer,Ariel Kaplan,Jeffrey R. Moffitt,Yann R. Chemla,Yann R. Chemla,Shelley Grimes,Paul J. Jardine,Dwight L. Anderson,Carlos Bustamante +9 more
TL;DR: By challenging the genome packaging motor of the Bacillus subtilis bacteriophage ϕ29 with a variety of modified DNA substrates, it is shown that during the dwell phase important contacts are made with adjacent phosphates every 10-bp on the 5′–3′ strand in the direction of packaging, which regulates the chemical cycle.
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Direct visualization of individual DNA molecules by fluorescence microscopy: characterization of the factors affecting signal/background and optimization of imaging conditions using YOYO
TL;DR: The factors affecting the signal/background in the imaging of single DNA molecules by fluorescence microscopy are characterized and the results obtained using YOYO-1 are compared with those obtained using standard fluorescent dyes like ethidium bromide or acridine orange.