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Mark Gerstein

Researcher at Yale University

Publications -  802
Citations -  172183

Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.

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Journal ArticleDOI

Simulation of water around a model protein helix. 2. The relative contributions of packing, hydrophobicity, and hydrogen bonding

Mark Gerstein, +1 more
- 01 Mar 1993 - 
TL;DR: In this paper, the relative importance of pacting, protein-water hydrogen bonding, and water water hydrogen bonding in creating a water structure around a polyalanine a-helix was assessed.

Digging for Dead Genes: An Analysis of the Characteristics of the Pseudogene Population in the C. elegans Genome

Paul M. Harrison, +2 more
TL;DR: An initial estimate of the size, distribution and characteristics of the pseudogene population in the Caenorhabditis elegans genome is derived by performing a survey in ‘molecular archaeology’, indicating a highly dynamic genome.
Posted ContentDOI

SVFX: a machine-learning framework to quantify the pathogenicity of structural variants

Sushant Kumar, +3 more
- 19 Aug 2019 - 
TL;DR: An agnostic machine-learning-based workflow, called SVFX, is built to assign a “pathogenicity score” to somatic and germline SVs in various diseases and found that predicted pathogenic SVS in cancer cohorts were enriched among known cancer genes and many cancer-related pathways.
Journal ArticleDOI

Predicting protein ligand binding motions with the conformation explorer

Samuel C. Flores, +1 more
- 27 Oct 2011 - 
TL;DR: This work describes how to generate ligand binding conformations of proteins that move by hinge bending, the largest class of motions, and demonstrates that the method in most cases successfully predicts the holo conformation given only an apo structure.
Posted ContentDOI

Broad transcriptomic dysregulation across the cerebral cortex in ASD

Jillian R. Haney, +22 more
- 18 Dec 2020 - 
TL;DR: It is determined that regional variation in the magnitude of transcriptomic dysregulation reflects changes in cellular proportion and cell-type-specific gene expression, particularly impacting L3/4 excitatory neurons.