Mark Gerstein

TL;DR: In this article, the water structure around a model α-helix in solution is investigated by molecular simulation and a marked contrast is seen between the hydration of the α and β carbons on one side of the helix axis and of the carbonyl oxygen on the other side.

TL;DR: The Functional Annotation of Variants Online Resources (FAVOR) is developed, a comprehensive online multi-faceted portal with summarization and visualization of all possible 9 billion single nucleotide variants across the genome, and allows for rapid variant-, gene-, and region-level online queries.

TL;DR: The round table participants perceived the quality assurance standard to be important, but identified some practical process challenges that included the broad scope and complexity of the device universe, the need for a multiphase testing pathway, and the associated fees for product evaluation.

TL;DR: The number of faculty position hires at 51 US universities in 3-year bins and the recent increase in hiring coincides with the explosion in sequencing data.

TL;DR: This article characterized the transcriptional profiles of a large and heterogeneous collection of mouse tissues, augmenting the mouse transcriptome with thousands of novel transcript candidates, and revealed a distinct class of genes with levels of expression across cell types and species, that have been constrained early in vertebrate evolution.