M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
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Journal ArticleDOI
Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression
Pei-Chun Lin,Ya-Lin Chiu,Samprit Banerjee,Kyung Park,Juan Miguel Mosquera,Eugenia G. Giannopoulou,P. Alves,Ashutosh K. Tewari,Mark Gerstein,Himisha Beltran,Ari Melnick,Olivier Elemento,Francesca Demichelis,Mark A. Rubin +13 more
TL;DR: This study examined primary and metastatic prostate cancer and found that miR-31 expression was reduced as a result of promoter hypermethylation, and importantly, the levels of miR -31 expression were inversely correlated with the aggressiveness of the disease.
Journal ArticleDOI
Integrative Personal Omics Profiles during Periods of Weight Gain and Loss
Brian D. Piening,Wenyu Zhou,Kévin Contrepois,Hannes L. Röst,Gucci Jijuan Gu Urban,Gucci Jijuan Gu Urban,Tejaswini Mishra,Blake M. Hanson,Eddy J. Bautista,Shana R. Leopold,Christine Y. Yeh,Daniel Spakowicz,Imon Banerjee,Cynthia Chen,Kimberly R. Kukurba,Dalia Perelman,Colleen M. Craig,Elizabeth Colbert,Denis Salins,Shannon Rego,Sunjae Lee,Cheng Zhang,Jessica Wheeler,M. Reza Sailani,Liang Liang,Charles Abbott,Mark Gerstein,Adil Mardinoglu,Adil Mardinoglu,Ulf Smith,Daniel L. Rubin,Sharon J. Pitteri,Erica Sodergren,Tracey McLaughlin,George M. Weinstock,Michael Snyder +35 more
TL;DR: A controlled longitudinal weight perturbation study combining multiple omics strategies during periods of weight gain and loss in humans demonstrated that weight gain is associated with the activation of strong inflammatory and hypertrophic cardiomyopathy signatures in blood.
Proceedings Article
Using Iterative Dynamic Programming to Obtain Accurate Pairwise and Multiple Alignments of Protein Structures
Mark Gerstein,Michael Levitt +1 more
TL;DR: It is shown how a basic pairwise alignment procedure can be improved to more accurately align conserved structural regions, by using variable, position-dependent gap penalties that depend on secondary structure and by taking the consensus of a number of suboptimal alignments.
Journal ArticleDOI
Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization
Yuichiro Mishima,Cei Abreu-Goodger,Alison A Staton,Carlos Stahlhut,C. Shou,Chao Cheng,Mark Gerstein,Anton J. Enright,Antonio J. Giraldez +8 more
TL;DR: Results suggest thatmiR-1 and miR-133 actively shape gene expression patterns in muscle tissue, where they regulate sarcomeric actin organization.
Journal ArticleDOI
Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.
TL;DR: A pipeline to detect human unitary pseudogenes through analyzing the global inventory of orthologs between the human genome and its mammalian relatives is developed and it is shown that for a group of 76, the functional genes appear to be disabled at a fairly uniform rate throughout primate evolution.