Mark Gerstein

TL;DR: The authors suggest that the chimeric WWTR1/CAMTA1 transcription factor may represent a therapeutic target for EHE-specific drugs and initiate an ill-suited and ill-timed transcriptional program that may play a role in cancer biology.

TL;DR: A DNA microarray representing nearly all of the unique sequences of human Chromosome 22 was constructed and used to measure global-transcriptional activity in placental poly(A)(+) RNA and revealed twice as many transcribed bases as have been reported previously.

TL;DR: Of the first 10 structures determined, several provided clues to biochemical functions that were not detectable from sequence analysis, and in many cases these putative functions could be readily confirmed by biochemical methods, demonstrating that structural proteomics is feasible and can play a central role in functional genomics.

TL;DR: In this article, an approach for assessing the significance of sequence and structure comparisons by using nearly identical statistical formalisms for both se- quence and structure is presented. But the approach is restricted to protein sequences and does not consider protein structures.

TL;DR: Motions related to protein-protein binding events can be surveyed from the perspective of the Database of Macromolecular Movements, whereby proteins are found to simultaneously exist in populations of diverse conformations.