Mark Gerstein

TL;DR: This first time such a relationship between mRNA and protein in terms of simultaneous changes in their levels over multiple time points is studied, and it is found that it gives a much stronger correlation, consistent with the hypothesis that a substantial proportion of protein change is a consequence of changed mRNA levels, rather than posttranscriptional effects.

TL;DR: An integrated online system that enables comparative analyses with a comprehensive set of commonly used scoring functions, including Statistical Coupling Analysis (SCA), Explicit Likelihood of Subset Variation (ELSC), mutual information and correlation-based methods is developed.

TL;DR: An overview of the emerging field of structural genomics is given, describing how genomes can be compared in terms of protein structure, and finding that microbial genomes have similar fractions of strands and helices even though they have significantly different amino acid composition.

TL;DR: The comprehensive variant dataset from the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes project is leveraged to demonstrate that-in addition to the dichotomy of high- and low-impact variants-there is a third group of medium-impact putative passengers, including undetected weak drivers.

TL;DR: It is proposed that scale development was an innovation that provided protection against injuries or stress and reduced pangolin vulnerability to infection, and perhaps a new natural IFNE-deficient animal model for studying mammalian immunity.