M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
Papers
More filters
Journal ArticleDOI
The reality of pervasive transcription
Michael B. Clark,Paulo P. Amaral,Felix Schlesinger,Marcel E. Dinger,Ryan J. Taft,John L. Rinn,Chris P. Ponting,Peter F. Stadler,Kevin V. Morris,Antonin Morillon,Joel Rozowsky,Mark Gerstein,Claes Wahlestedt,Yoshihide Hayashizaki,Piero Carninci,Thomas R. Gingeras,John S. Mattick +16 more
TL;DR: Despite recent controversies, the evidence that the majority of the human genome is transcribed into RNA remains strong.
Journal ArticleDOI
3V: cavity, channel and cleft volume calculator and extractor
Neil R. Voss,Mark Gerstein +1 more
TL;DR: The 3V web server can automatically extract and comprehensively analyze all the internal volumes from input RNA and protein structures, and produces volumetric representations, both as images and downloadable files, which can be used for further analysis.
Journal ArticleDOI
Role of non-coding sequence variants in cancer
Ekta Khurana,Yao Fu,Dimple Chakravarty,Francesca Demichelis,Francesca Demichelis,Mark A. Rubin,Mark Gerstein +6 more
TL;DR: The current understanding of non-coding variants in cancer is reviewed, including the great diversity of the mutation types — from single nucleotide variants to large genomic rearrangements — and the wide range of mechanisms by which they affect gene expression to promote tumorigenesis.
Journal ArticleDOI
Annotating non-coding regions of the genome
TL;DR: This work focuses on annotating non-protein-coding regions of the human genome through the interpretation of functional genomics experiments and comparative sequence analysis, and can relate these annotations to conserved units and measures of conservation derived from comparative sequences analysis.
Journal ArticleDOI
Electron diffraction analysis of structural changes in the photocycle of bacteriorhodopsin.
TL;DR: Electro diffraction studies with two‐dimensional crystals of wild‐type bacteriorhodopsin and the Asp96‐‐>Gly mutant reveal the structure of the M intermediate, which occurs between the proton release and uptake steps of the photocycle.