M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
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An integrative ENCODE resource for cancer genomics
Jing Zhang,Dong-Hoon Lee,Vineet K. Dhiman,Peng Jiang,Peng Jiang,Jie Xu,Jie Xu,Patrick McGillivray,Hongbo Yang,Jason Liu,William Meyerson,Declan Clarke,Mengting Gu,Shantao Li,Shaoke Lou,Jinrui Xu,Lucas Lochovsky,Matthew Ung,Lijia Ma,Lijia Ma,Shan Yu,Qin Cao,Arif Harmanci,Koon-Kiu Yan,Anurag Sethi,Gamze Gürsoy,Michael Rutenberg Schoenberg,Joel Rozowsky,Jonathan Warrell,Prashant Emani,Yucheng T. Yang,Timur R. Galeev,Xiangmeng Kong,Shuang Liu,Xiaotong Li,Jayanth Krishnan,Yanlin Feng,Juan Carlos Rivera-Mulia,Juan Carlos Rivera-Mulia,Jessica Adrian,James R. Broach,Michael J. Bolt,Jennifer R. Moran,Dominic Fitzgerald,Vishnu Dileep,Tingting Liu,Shenglin Mei,Takayo Sasaki,Claudia Trevilla-Garcia,Claudia Trevilla-Garcia,Su Wang,Yanli Wang,Chongzhi Zang,Daifeng Wang,Robert J. Klein,Michael Snyder,David M. Gilbert,Kevin Y. Yip,Chao Cheng,Chao Cheng,Feng Yue,Feng Yue,X. Shirley Liu,Kevin P. White,Mark Gerstein +64 more
TL;DR: A custom annotation within ENCODE for cancer is presented, highlighting a workflow that can help prioritise key elements in oncogenesis and targeted validations of the prioritized regulators, elements and variants using siRNA knockdowns, CRISPR-based editing, and luciferase assays demonstrate the value of the E NCODE resource.
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Analysis of genomic variation in non-coding elements using population-scale sequencing data from the 1000 Genomes Project
TL;DR: It is found that both micro-RNAs and their binding targets are under stronger selective pressure for SNPs than their immediate genomic surroundings, and SVs have the tendency to use distinctive modes and mechanisms when they interact with genomic elements, such as enveloping whole gene(s) rather than disrupting them partially.
Journal ArticleDOI
Genomic analysis of the hydrocarbon-producing, cellulolytic, endophytic fungus Ascocoryne sarcoides.
Tara A. Gianoulis,Tara A. Gianoulis,Tara A. Gianoulis,Meghan A. Griffin,Daniel Spakowicz,Brian F. Dunican,Cambria J. Alpha,Andrea Sboner,A. Michael Sismour,A. Michael Sismour,Chinnappa D. Kodira,Michael Egholm,George M. Church,George M. Church,Mark Gerstein,Scott A. Strobel +15 more
TL;DR: This is one of the highest quality fungal genomes and, to the authors' knowledge, the only thoroughly annotated and transcriptionally profiled fungal endophyte genome currently available and provides the genomic foundation for the study of a model endophytes system.
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The relationship between the evolution of microRNA targets and the length of their UTRs
TL;DR: A systematic investigation of the relationship between miRNA regulation and their targets' evolution in two mammals: human and mouse finds genes with longer 3' UTRs are regulated by more distinct types of miRNAs.