M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
Papers
More filters
Journal ArticleDOI
Hinge Atlas: relating protein sequence to sites of structural flexibility
TL;DR: A Hinge Atlas of manually annotated hinges and a statistical formalism for calculating the enrichment of various types of residues in these hinges found that hinges tend to coincide with active sites, but unlike the latter they are not at all conserved in evolution.
Journal ArticleDOI
Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism
TL;DR: It is suggested that noncovalent oligomeric associations, which are common in membrane proteins, may provide an alternative source of evolutionary diversity.
Journal ArticleDOI
Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs.
Michelle M. Kudron,Wei Niu,Zhi Lu,Zhi Lu,Guilin Wang,Mark Gerstein,Michael Snyder,Valerie Reinke +7 more
TL;DR: Identification of tissue-specific binding profiles and effector target genes reveals important insights into the mechanisms by which Rb/E2F controls distinct cell fates in vivo.
Journal ArticleDOI
The human genome has 49 cytochrome c pseudogenes, including a relic of a primordial gene that still functions in mouse.
Zhaolei Zhang,Mark Gerstein +1 more
TL;DR: The study may have identified a pseudogene that is a dead relic of a gene that has completely died off in the human lineage, and this results support the observation that accelerated evolution in cyc sequence had occurred in the primate lineage.
Journal ArticleDOI
Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition.
Vladimir Despic,Mario Dejung,Mengting Gu,Jayanth Krishnan,Jing Zhang,Lydia Herzel,Korinna Straube,Mark Gerstein,Falk Butter,Karla M. Neugebauer +9 more
TL;DR: This study identifies global changes in RNA-protein interactions during vertebrate MZT and shows that Hnrnpa1 RNA-binding activities are spatially and temporally coordinated to regulate RNA metabolism during early development.