Mark Gerstein

TL;DR: Cloned and functionally characterized ASIC1 from different species of the chordate lineage and observed that ASIC1s from early vertebrates were proton insensitive in spite of a high degree of amino acid conservation with their mammalian counterparts, implying that agonists different from protons activate ASIC1 in lower vertebrates.

TL;DR: This work assess reproducibility and quality measures by varying sequencing depth, resolution and noise levels in Hi-C data from 13 cell lines, with two biological replicates each, as well as 176 simulated matrices.

TL;DR: The total ancestry measure is based on counting the number of leaf nodes that share exactly the same set of 'higher up' category nodes in comparison to the total number of classified pairs and is associated with a power-law distribution, allowing for the quick assessment of the statistical significance of shared functional annotations.

TL;DR: This study reveals extensive sites of poly(A) addition and provides insights into the events that occur during 3' end formation, and suggests transcription termination loss of histone 3 lysine 36 methylation and later release of RNA polymerase.

TL;DR: Proteomics should be exploited to enhance high-throughput functional genomic analysis by tighter integration of data analyses and experimental strategies to achieve finer cellular and subcellular resolution in transcriptomic and proteomic studies of neural tissues are discussed.