Mark Gerstein

TL;DR: The co- localization of SDs is analyzed and it is found that SDs are significantly co-localized with each other, resulting in a power-law distribution, which suggests a preferential attachment mechanism, i.e. existingSDs are likely to be involved in creating new ones nearby.

TL;DR: Recent and ongoing efforts to build gene regulatory maps, which aim to characterize all sequences in a genome for their roles in regulating gene expression, are discussed.

TL;DR: It is shown that disruption of genetic regulatory elements in the noncoding genome correlates with altered gene expression, and overall functional burdening of various genomic elements correlate with patient survival time, and tumor clonality.

TL;DR: The solution to a basic online interval maximum problem via a sliding-window approach is discussed and how to use this solution in a nontrivial manner for many of the tiling problems introduced.

TL;DR: The Intensification approach is developed, which uses the modular structure of repeat protein domains to amplify signals of selection from population genetics and traditional interspecies conservation, and is able to aggregate variants at the codon level to identify important positions in repeat domains that show strong conservation signals.