M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
Papers
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Proceedings Article
Finding an average core structure: Application to the globins
Russ B. Altman,Mark Gerstein +1 more
TL;DR: The structural core of the globin family of proteins is used as a reference point for automatically identifying from a set of aligned protein structures a subset of atoms with only a small amount of structural variation, i.e., a core.
Journal ArticleDOI
Novel approaches for bioinformatic analysis of salivary RNA sequencing data for development.
Karolina Elżbieta Kaczor-Urbanowicz,Yong Kim,Feng Li,Timur R. Galeev,Robert R. Kitchen,Mark Gerstein,Kikuye Koyano,Sung-Hee Jeong,Xiaoyan Wang,David Elashoff,So Young Kang,Su Mi Kim,Kyoung Ah Kim,Sung Kim,David Chia,Xinshu Xiao,Joel Rozowsky,David T.W. Wong +17 more
TL;DR: Alignment to exogenous genomes and their quantification results were used in this paper for the analyses of small RNAs of exogenous origin and they revealed that almost all of the reads map to bacterial genomes.
Posted ContentDOI
Centers for Mendelian Genomics: A decade of facilitating gene discovery
Samantha Baxter,Jennifer E. Posey,Nicole J. Lake,Nara Sobreira,Jessica X. Chong,Steven Buyske,Elizabeth E. Blue,Lisa Helbling Chadwick,Zeynep Coban-Akdemir,Zeynep Coban-Akdemir,Kimberly F. Doheny,Colleen P. Davis,Monkol Lek,Monkol Lek,Christopher Wellington,Shalini N. Jhangiani,Mark Gerstein,Richard A. Gibbs,Richard A. Gibbs,Richard P. Lifton,Richard P. Lifton,Daniel G. MacArthur,Daniel G. MacArthur,Tara C. Matise,James R. Lupski,James R. Lupski,David Valle,Michael J. Bamshad,Michael J. Bamshad,Ada Hamosh,Shrikant Mane,Deborah A. Nickerson,Heidi L. Rehm,Heidi L. Rehm,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria +36 more
TL;DR: Mendelian disease genomic research has undergone a massive transformation over the last decade as discussed by the authors, and the role of Mendelian research has expanded beyond data collection, sequencing, and analysis to worldwide data sharing and collaboration.
Journal ArticleDOI
The Development of a Practical Artificial Intelligence Tool for Diagnosing and Evaluating Autism Spectrum Disorder: Multicenter Study
Tao Chen,Ye Chen,Mengxue Yuan,Mark Gerstein,Tingyu Li,Huiying Liang,Tanya E. Froehlich,Long Lu +7 more
TL;DR: It is suggested that it is possible to identify neuroimaging biomarkers that can distinguish patients with ASD from healthy controls based on the more cost-effective sMRI images of the brain.
Journal ArticleDOI
TopicNet: a framework for measuring transcriptional regulatory network change.
TL;DR: A method called TopicNet is proposed that applies latent Dirichlet allocation to extract functional topics for a collection of genes regulated by a given TF, and a rewiring score is defined to quantify regulatory-network changes in terms of the topic changes for this TF.