M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
Papers
More filters
Proceedings ArticleDOI
GersteinLab at MEDIQA-Chat 2023: Clinical Note Summarization from Doctor-Patient Conversations through Fine-tuning and In-context Learning
TL;DR: This paper proposed a few-shot in-context learning (ICL) approach to the MEDIQA-2023 Dialogue2Note shared task, which achieved excellent results in terms of ROUGE-1 F1, BERTScore F1 (deberta-xlarge-mnli), and BLEURT, with scores of 0.4011, 0.7058, and 0.5421, respectively.
Journal ArticleDOI
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.
Michael J. Koenig,Bernice A. Agana,Jacob M. Kaufman,Michael F. Sharpnack,Walter Wang,Christoph Weigel,Fabio C. P. Navarro,Joseph M. Amann,Nicole Cacciato,Rajeswara Rao Arasada,Mark Gerstein,Vicki H. Wysocki,Christopher C. Oakes,David P. Carbone +13 more
TL;DR: In this article, the authors identified a 16-gene signature for LKB1 loss of function through mutational and non-mutational mechanisms and applied this genetic signature to TCGA lung adenocarcinoma samples and discovered a novel association between LK1 loss and widespread DNA demethylation.
Journal ArticleDOI
GRAM: A GeneRAlized Model to Predict the Molecular Effect of a Non-Coding Variant in a Cell-Type Specific Manner
Shaoke Lou,Kellie A. Cotter,Tianxiao Li,Jin Liang,Hussein Mohsen,Jason Liu,Jing Zhang,Sandra Cohen,Jinrui Xu,Haiyuan Yu,Mark A. Rubin,Mark A. Rubin,Mark Gerstein +12 more
TL;DR: This work coupled multiple genomic predictors to build GRAM, a GeneRAlized Model, to predict a well-defined experimental target: the expression-modulating effect of a non-coding variant on its associated gene, in a transferable, cell-specific manner.
Posted ContentDOI
Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex
Shuang Liu,Hyejung Won,Declan Clarke,Nana Matoba,Saniya Khullar,Yudi Mu,Daifeng Wang,Mark Gerstein +7 more
TL;DR: In this paper, the authors conduct a genome-wide survey of trans-eQTLs in the dorsolateral prefrontal cortex (DLPFC) by leveraging the large datasets from the PsychENCODE consortium.
Journal ArticleDOI
Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
Pei Ling Tsai,Christopher J. F. Cameron,Maria Fernanda Forni,Renee R. Wasko,Brigitte S Naughton,Valerie Horsley,Mark Gerstein,Christian Schlieker +7 more
TL;DR: In this paper , the authors employ a short-lived Lamin B receptor disease variant as a model substrate in a genetic screen to uncover key elements of nuclear envelope (NE) protein turnover.