Mark Gerstein

TL;DR: From perspectives on how network analysis represents a preliminary step toward a systems approach for modeling cells, approaches for characterizing the topology of networks, such as finding hubs and analyzing subnets in terms of common motifs are discussed.

TL;DR: A probabilistic system for predicting the subcellular localization of proteins and estimating the relative population of the various compartments in yeast, based on a Bayesian approach, which gives better accuracy in determining relative compartment populations than that obtained by simply tallying the localization predictions for individual proteins.

TL;DR: The results imply that a shift in predominant formation mechanism occurred in recent history: approximately 40 million years ago, during the "Alu burst" in retrotransposition activity, non-allelic homologous recombination was the main driver of genome rearrangements.

TL;DR: The database of molecular motions, MolMovDB (), has been in existence for the past decade and provides tools to interpolate between two conformations (the Morph Server) and predict possible motions in a single structure and developed tools to relate points of flexibility in a structure to particular key residue positions.

TL;DR: The structural mechanism underlying Lactoferrin's domain closure is analyzed here in detail and is compared to other instances of hinged domain closure and contrasted with instances of shear domain closure, where the overall motion is a summation of many small sliding motions between close-packed segments of polypeptide.