M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
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Journal ArticleDOI
MetaSV: an accurate method-aware merging algorithm for structural variations
Marghoob Mohiyuddin,John C. Mu,Jian Li,Narges Bani Asadi,Mark Gerstein,Alexej Abyzov,Wing Hung Wong,Hugo Y. K. Lam +7 more
Posted ContentDOI
Capped nascent RNA sequencing reveals novel therapy-responsive enhancers in prostate cancer
Kellie A. Cotter,Sagar R. Shah,Mauricio Paramo,Shaoke Lou,Li Yao,Philip D. Rubin,You Chen,Mark Gerstein,Mark A. Rubin,Haiyuan Yu +9 more
TL;DR: In vivo functional validations of candidate enhancers found that CRISPRi targeting of PRO-cap-specific drug-responsive enhancers impaired ENZ regulation of downstream target genes, suggesting that changes in eRNA TSSs mark true biological changes in enhancer activity with high sensitivity.
Posted ContentDOI
Genetic determination of regional connectivity in modelling the spread of COVID-19 outbreak for improved mitigation strategies
TL;DR: In this article, a case study of the Covid-19 outbreak with respect to phylogenetic information, viral migration, inter-and intra-regional connectivity, epidemiologic and demographic characteristics is presented.
Posted Content
Rank Projection Trees for Multilevel Neural Network Interpretation.
TL;DR: A flexible framework which may be used to generate multiscale network interpretations, using any previously defined scoring function is outlined, and the ability of the method to pick out biologically important genes and gene sets in the domains of cancer and psychiatric genomics is demonstrated.
Journal ArticleDOI
ACCOORD - An ensemble methodology for cryo-EM particle picking.
TL;DR: In this article , a consensus algorithm is proposed to reduce false positives introduced by individual methods and improve particle identification using a consensus method using a set of particle identification algorithms. But their algorithm is limited due to differences in their algorithm and model-training strategies.