Mark Gerstein

TL;DR: The Database of Macromolecular Movements (MolMovDB), a collection of data and software pertaining to flexibility in protein and RNA structures, has been greatly expanded and enhanced to incorporate new structures and to improve the quality of data.

TL;DR: A mass spectrometry assay is developed for the large-scale identification of in vivo protein-hydrophobic small metabolite interactions in yeast and compounds that bind ergosterol biosynthetic proteins and protein kinases are analyzed.

TL;DR: This work has systematically identified approximately 5000 processed pseudogenes in the mouse genome, and estimated that approximately 60% are lineage specific, created after the mouse and human diverged.

TL;DR: It is demonstrated that organoids from human pluripotent cells model cerebral cortical development on the molecular level before 16 weeks postconception, and validated hiPSC-derived cortical organoids as a suitable model system for studying gene regulation in human embryonic brain development, evolution, and disease.

TL;DR: The term "translatome" is suggested to describe the members of the proteome weighted by their abundance, and the "functome" to describe all the functions carried out by these in the cellular contents of the genome.