R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Macrophage Migration Inhibitory Factor Promotes Clearance of Pneumococcal Colonization
Rituparna Das,Meredith I. LaRose,Christopher B. Hergott,Lin Leng,Richard Bucala,Jeffrey N. Weiser +5 more
TL;DR: It is suggested that MIF is important for innate and adaptive immunity to pneumococcal colonization and could be a contributing factor in genetic differences in pneumococCal disease susceptibility.
CD74-dependent Deregulation of the Tumor Suppressor Scribble in Human Epithelial and Breast
Gergana Metodieva,Naiara Correa Nogueira-de-Souza,Christina Greenwood,Khalid Al-Janabi,Lin Leng,Richard Bucala,Metodi V. Metodiev +6 more
TL;DR: In this paper, the authors show that when CD74 is overexpressed in human cancer and non-cancerous epithelial cells, it interacts and interferes with the function of Scribble, a product of a well-known tumor suppressor gene.
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Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors
Yoonsang Cho,Jon J. Vermeire,Jane S. Merkel,Lin Leng,Xin Du,Richard Bucala,Michael Cappello,Elias Lolis +7 more
TL;DR: Vaccination with recombinant Ancylostoma ceylanicum macrophage migration inhibitory factor (rAceMIF) provided partial protection from disease, thus establishing a "proof-of-concept" for targeting AceMIF to prevent or treat infection.
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MiRNA Regulation of MIF in SLE and Attenuation of Murine Lupus Nephritis With miR-654.
TL;DR: In vivo miR-654 treatment decreases MIF and downstream cytokine production and ameliorates murine lupus nephritis and explores specific miRNAs that can regulate MIF expression.
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Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury
Maor Sauler,Yi Zhang,Jin-Na Min,Lin Leng,Peiying Shan,Scott C. Roberts,William L. Jorgensen,Richard Bucala,Patty J. Lee +8 more
TL;DR: Data suggest that therapeutic manipulation of the MIF‐CD74 axis in lung endothelial cells may be a novel approach to protect against acute oxidative stress.