R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.
Melanie Merk,John A. Baugh,Swen Zierow,Lin Leng,Utpal Pal,Seung Joon Lee,Antje D. Ebert,Yuka Mizue,John O. Trent,Robert F. Mitchell,Walter Nickel,Paula B. Kavathas,Jürgen Bernhagen,Richard Bucala +13 more
TL;DR: P115 is identified as a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages and the small molecule MIF inhibitor 4-iodo-6-phenylpyrimidine inhibits MIF secretion by targeting the interaction between MIF and p115.
Journal ArticleDOI
Macrophage migration inhibitory factor and autism spectrum disorders.
Elena L. Grigorenko,Summer S. Han,Carolyn M. Yrigollen,Lin Leng,Yuka Mizue,George M. Anderson,Erik J. Mulder,Annelies de Bildt,Ruud B. Minderaa,Fred R. Volkmar,Jin Chang,Richard Bucala +11 more
TL;DR: These results identify MIF as a possible susceptibility gene for autism spectrum disorder and the precise relationship between MIF and the behavioral components of autistic spectrum disorder is unclear.
Journal ArticleDOI
Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis
Rituparna Das,Mi Sun Koo,Bae Hoon Kim,Shevin T. Jacob,Selvakumar Subbian,Jie Yao,Lin Leng,Rebecca Levy,Charles Murchison,William J. Burman,Christopher C. Moore,W. Michael Scheld,John R. David,Gilla Kaplan,John D. MacMicking,Richard Bucala +15 more
TL;DR: The role of macrophage migration inhibitory factor (MIF), a cytokine that is encoded in a functionally polymorphic locus in humans, in TB is examined and genetic low expressers of MIF to be enriched in a population of patients with HIV and disseminated TB.
Journal ArticleDOI
Association Between Acute-Phase Reactants and Advanced Glycation End Products in Type 2 Diabetes
TL;DR: Serum concentration of AGEs is increased in patients with diabetes and is an independent determinant of plasma CRP levels, suggesting that subclinical inflammation in these patients may be partly due to activation of the inflammatory response by A GEs.
Journal ArticleDOI
The Proinflammatory Cytokine Macrophage Migration Inhibitory Factor Regulates Glucose Metabolism during Systemic Inflammation
Toshiya Atsumi,You-Ree Cho,Lin Leng,Courtney McDonald,Timothy W. Yu,Cheryl Danton,Eun-Gyoung Hong,Robert A. Mitchell,Christine N. Metz,Hirokatsu Niwa,Jun Takeuchi,Shin Onodera,Tomomi Umino,Narihito Yoshioka,Takao Koike,Jason K. Kim,Richard Bucala +16 more
TL;DR: An important role for MIF in host glucose metabolism during sepsis is support by investigating the glycemic responses of endotoxemic mice genetically deficient in MIF, which exhibits normal blood glucose and lactate responses following the administration of endotoxin.