R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Interaction of borrelia burgdorferi with peripheral blood fibrocytes, antigen-presenting cells with the potential for connective tissue targeting
TL;DR: This interaction between B. burgdorferi and peripheral blood fibrocytes provides a potential explanation for the targeting of spirochetes to joint connective tissue and may contribute to the inflammatory process in Lyme arthritis.
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Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus
Jie Yao,Lin Leng,Maor Sauler,Weiling Fu,Junsong Zheng,Yi Zhang,Xin Du,Xiaoqing Yu,Patty J. Lee,Richard Bucala +9 more
TL;DR: It is found that ICBP90 is essential for Mif transcription from monocytes/macrophages, B and T lymphocytes, and synovial fibroblasts, and TLR-induced MIF transcription is regulated in an ICBP 90- and -794 CATT5-8 length-dependent manner.
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The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
Farah El-Turk,Michele Cascella,Hajer Ouertatani-Sakouhi,Raghaverndran Lakshmi Narayanan,Lin Leng,Richard Bucala,Markus Zweckstetter,Ursula Rothlisberger,Hilal A. Lashuel +8 more
TL;DR: These studies demonstrate that intersubunit interactions involving the C-terminal region 105-114 play critical roles in modulating tertiary structure stabilization, enzymatic activity, and thermodynamic stability of MIF, but not its oligomerization state and receptor binding properties.
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Macrophage migration inhibitory factor inhibits the antiinflammatory effects of glucocorticoids via glucocorticoid-induced leucine zipper.
Huapeng Fan,Wenping Kao,Yuan Hang Yang,Ran Gu,James Harris,Gunter Fingerle-Rowson,Richard Bucala,Devi Ngo,Elaine Beaulieu,Eric F Morand +9 more
TL;DR: This study investigates whether GILZ is involved in the regulation of glucocorticoid sensitivity by MIF, a proinflammatory protein implicated in the pathogenesis of rheumatoid arthritis.
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Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis
D Heinrichs,Marie-Luise Berres,Melanie Coeuru,Meike Knauel,A Nellen,P Fischer,Claudia Philippeit,Richard Bucala,Christian Trautwein,Hermann E. Wasmuth,Jürgen Bernhagen +10 more
TL;DR: It is demonstrated that MIF mediates hepatoprotection through the CD74/AMPK pathway in hepatocytes in metabolic models of liver injury in high‐fat or methionine‐ and choline‐deficient diet mouse models of NASH.