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Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients
Christian Stoppe,Steffen Rex,Andreas Goetzenich,Sandra Kraemer,Christoph Emontzpohl,Josefin Soppert,Luisa Averdunk,Yu Sun,Yu Sun,Rolf Rossaint,Hongqi Lue,Caleb Huang,Yan Song,Georgios Pantouris,Elias Lolis,Lin Leng,Wibke Schulte,Richard Bucala,Christian Weber,Jürgen Bernhagen,Jürgen Bernhagen +20 more
TL;DR: It is suggested that increased MIF levels during cardiac surgery feature organ-protective properties during myocardial I/R, while the soluble MIF receptor, sCD74, may enhance MIF antioxidant activity.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome.
Min Sun Shin,Youna Kang,Elizabeth Wahl,Hong-Jai Park,Rossitza Lazova,Lin Leng,Mark J. Mamula,Smita Krishnaswamy,Richard Bucala,Insoo Kang +9 more
TL;DR: The role of the snRNP immune complex in up‐regulating the expression of MIF and its interface with the NLRP3 inflammasome is investigated.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
Xihui Xu,Jiaojiao Pang,Jiaojiao Pang,Yu-Guo Chen,Richard Bucala,Yingmei Zhang,Yingmei Zhang,Jun Ren,Jun Ren +8 more
TL;DR: It is indicated that MIF knockout exacerbates aging-induced cardiac remodeling and functional anomalies despite improved inflammation, probably through attenuating loss of autophagy and ATP availability in the heart.
Journal ArticleDOI
Induction of MIF synthesis and secretion by tubular epithelial cells: a novel action of angiotensin II.
Edwina K Rice,Gregory H Tesch,Zemin Cao,Mark E. Cooper,Christine N. Metz,Richard Bucala,Robert C. Atkins,David J. Nikolic-Paterson +7 more
TL;DR: It is demonstrated that Ang II up-regulates MIF mRNA production and MIF protein secretion by tubular epithelial cells, which may be an important mechanism by which Ang II mediates renal injury.
Journal ArticleDOI
c-Met and Its Ligand Hepatocyte Growth Factor/Scatter Factor Regulate Mature B Cell Survival in a Pathway Induced by CD74
Maya Gordin,Melania Tesio,Sivan Cohen,Yael Gore,Frida Lantner,Lin Leng,Richard Bucala,Idit Shachar +7 more
TL;DR: It is demonstrated that c-Met activation by HGF leads to a survival cascade, whereas its blockade results in induction of mature B cell death, resulting in the control of the humoral immune response.