R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
Papers
More filters
Journal Article
Macrophage migration inhibitory factor upregulates angiogenic factors and correlates with clinical measures in rheumatoid arthritis.
Hae-Rim Kim,Mi-Kyung Park,Mi-La Cho,Chong-Hyeon Yoon,Sang-Heon Lee,Sung-Hwan Park,Lin Leng,Richard Bucala,Insoo Kang,Jongseon Choe,Ho-Youn Kim +10 more
TL;DR: SF MIF may reflect the clinical activity in patients with RA, and rhMIF induces the angiogenic factors in RA synovial fibroblasts, and these results suggest that Mif may be an important cytokine in the perpetuation of theAngiogenic and inflammatory processes in Patients with RA.
Journal ArticleDOI
Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host.
Jason W. Griffith,Christine L. O’Connor,Ken Bernard,Terrence Town,Daniel R. Goldstein,Richard Bucala +5 more
TL;DR: It is shown that Toll-like receptor (TLR) signaling influences the development of lethal CM in P. berghei ANKA-infected mice through modulation of cytokine production and T(reg) cell numbers.
Journal ArticleDOI
Ribosomal Protein S19 Interacts with Macrophage Migration Inhibitory Factor and Attenuates Its Pro-inflammatory Function
Ana-Maria Filip,Jörg Klug,Sevil Cayli,Suada Fröhlich,Tamara Henke,Philipp Lacher,Regina Eickhoff,Patrick Bulau,Monika Linder,Christine Carlsson-Skwirut,Lin Leng,Richard Bucala,Sandra Kraemer,Jürgen Bernhagen,Andreas Meinhardt +14 more
TL;DR: It is proposed that the ribosomal protein S19 (RPS19) acts as an extracellular negative regulator of MIF, which is implicated in the pathogenesis of inflammatory disorders such as infection, sepsis, and autoimmune disease.
Journal ArticleDOI
Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii
Marcos Flores,Rafael Saavedra,Rocío Amador Bautista,Rubi Viedma,Eda Patricia Tenorio,Lin Leng,Yuriko Sanchez,Imelda Juárez,Anjali A. Satoskar,Asha S. Shenoy,Luis I. Terrazas,Richard Bucala,Joseph Barbi,Abhay R. Satoskar,Miriam Rodriguez-Sosa +14 more
TL;DR: Findings demonstrate that MIF plays a critical role in mediating host resistance against T. gondii and an analysis of brains from patients with cerebral toxoplasmosis showed low levels of MIF expression.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor Deficiency Augments Doxorubicin-Induced Cardiomyopathy
Xihui Xu,Richard Bucala,Jun Ren +2 more
TL;DR: It is suggested that MIF serves as an indispensable cardioprotective factor against doxorubicin‐induced cardiomyopathy with an underlying mechanism through facilitating autophagolysosome formation.