R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism.
Barry J. Plant,Charles G. Gallagher,Richard Bucala,John A. Baugh,Sally Chappell,Linda Morgan,Clare O'Connor,Kevin Morgan,Seamas C. Donnelly +8 more
TL;DR: The results support the concept of a regulatory role for MIF in CF, and a trend toward milder disease activity in the MIF5(+) group was seen with all other parameters.
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Nonenzymatic addition of glucocorticoids to lens proteins in steroid-induced cataracts.
TL;DR: It is concluded that elevated glucocorticoid levels lead to the formation of glucoc Corticoid-lens protein adducts both in vitro and in vivo.
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Evidence for a Role of Macrophage Migration Inhibitory Factor in Vascular Disease
Zhiping Chen,Masashi Sakuma,Alexandre do Canto Zago,Xiaobin Zhang,Can Shi,Lin Leng,Yuka Mizue,Richard Bucala,Daniel I. Simon +8 more
TL;DR: Neutralizing MIF bioactivity after experimental angioplasty in atherosclerosis-susceptible mice reduces vascular inflammation, cellular proliferation, and neointimal thickening and prompts further research directed at understanding the role of MIF in vascular disease.
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Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice.
Leilani Llanes Santos,Huapeng Fan,Pam Hall,Devi Ngo,Charles R. Mackay,Gunter Fingerle-Rowson,Richard Bucala,Michael J. Hickey,Eric F Morand +8 more
TL;DR: It is suggested that MIF promotes neutrophil trafficking in inflammatory arthritis via facilitation of chemokine-induced migratory responses and MAP kinase activation.
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Macrophage migration inhibitory factor induces MMP-9 expression: implications for destabilization of human atherosclerotic plaques.
Yao Zhong Kong,Xiyong Yu,Jia Ju Tang,Xiaosen Ouyang,Xiao R. Huang,Gunter Fingerle-Rowson,Michael Bacher,Larry A. Scher,Richard Bucala,Hui Y. Lan +9 more
TL;DR: MIF and MMP-9 are markedly upregulated in vulnerable atheromatous plaques, suggesting that MIF may play a role in the destabilization of human atherosclerotic plaques.