R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment.
TL;DR: In vivo generation of AGEs in the kidney is time dependent and closely linked to the development of experimental diabetic nephropathy, and renoprotective effects of aminoguanidine in diabetes appear to be related to the duration but not to the timing of treatment.
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Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies
Xiao-bo Zhong,Lin Leng,Anna Beitin,Rui Chen,Courtney McDonald,Betty Hsiao,Robert D. Jenison,Insoo Kang,Sung Hwan Park,Annette Lee,Peter K. Gregersen,Philip E. Thuma,Patricia Bray-Ward,Patricia Bray-Ward,David C. Ward,David C. Ward,Richard Bucala +16 more
TL;DR: A thin-film biosensor chip based on an allele-discriminating oligonucleotide array that enables genotyping for both microsatellite repeats and SNPs in a single analysis is described and first evidence for a potential association between MIF alleles and malaria infection is provided.
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Role of macrophage migration inhibitory factor (MIF) in murine antigen-induced arthritis: interaction with glucocorticoids
TL;DR: The concept that MIF is a counter‐regulator of glucocorticoid control of synovial inflammation is supported, as DTH and AIA are MIF‐dependent models of inflammation and arthritis and rMIF had no reversing effect on the suppression of DTH by glucOCorticoids.
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Impaired Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Activation and Ischemic Recovery in the Senescent Heart
Heng Ma,Jingying Wang,D. Paul Thomas,Chao Tong,Lin Leng,Wenkui Wang,Melanie Merk,Swen Zierow,Jürgen Bernhagen,Jun Ren,Richard Bucala,Ji Li +11 more
TL;DR: In the clinical setting, impaired cardiac hypoxia-inducible factor 1&agr; activation and consequent reduced MIF expression may play an important role in the increased susceptibility to myocardial ischemia observed in older cardiac patients.
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Macrophage migration inhibitory factor promotes intestinal tumorigenesis.
Jonathan Wilson,P. Louise Coletta,Richard Cuthbert,Nigel Scott,Kenneth A. MacLennan,Gillian Hawcroft,Lin Leng,Jodi B. Lubetsky,Kai K. Jin,Elias Lolis,Francisco Medina,José A. Brieva,Richard Poulsom,Alexander F. Markham,Alexander F. Markham,Richard Bucala,Mark A. Hull +16 more
TL;DR: MIF expression is increased in sporadic human colorectal adenomas, and exogenous MIF drives tumorigenic behavior of epithelial cells in vitro and promotes intestinal tumorigenesis in the ApcMin/+ mouse.