R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Cutting Edge: Deficiency of Macrophage Migration Inhibitory Factor Impairs Murine Airway Allergic Responses
Bing Wang,Xiaozhu Huang,Paul J. Wolters,Jiusong Sun,Shiro Kitamoto,Min Yang,Min Yang,Richard J. Riese,Lin Leng,Harold A. Chapman,Patricia W. Finn,John R. David,Richard Bucala,Guo-Ping Shi +13 more
TL;DR: Increased levels of macrophage migration inhibitory factor in serum, sputum, and bronchioalveolar lavage fluid from asthmatic patients and time/dose-dependent expression of MIF in eosinophils in response to phorbol myristate acetate suggest the participation of Mif in airway inflammation.
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Response of serum macrophage migration inhibitory factor levels to stimulation or suppression of the hypothalamo-pituitary-adrenal axis in normal subjects and patients with Cushing's disease
Andrea M. Isidori,Gregory Kaltsas,Márta Korbonits,M Pyle,Maria Gueorguiev,Andreas Meinhardt,Christine N. Metz,Nikolai Petrovsky,Vera Popovic,Richard Bucala,Ashley B. Grossman +10 more
TL;DR: The results show that in humans acute modulation of the hypothalamo-pituitary-adrenal axis does not significantly alter circulating MIF levels, and suggests that the pituitary gland is not the major contributor to circulate MIF; an autocrine or paracrine role for pituitsary-derived MIF is more likely.
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Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor.
Markus K. Dahlgren,Alvaro Baeza Garcia,Alissa A. Hare,Julian Tirado-Rives,Lin Leng,Richard Bucala,William L. Jorgensen +6 more
TL;DR: To identify small-molecule inhibitors of the tautomerase activity of PfMIF, virtual screening has been performed by docking 2.1 million compounds into the enzymatic site and identifying four compounds that were purchased and also shown to be active.
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MIF promotes a differential Th1/Th2/Th17 inflammatory response in human primary cell cultures: Predominance of Th17 cytokine profile in PBMC from healthy subjects and increase of IL-6 and TNF-α in PBMC from active SLE patients
Ulises De la Cruz-Mosso,Trinidad García-Iglesias,Richard Bucala,Iris Estrada-García,Laura Gonzalez-Lopez,Sergio Cerpa-Cruz,Isela Parra-Rojas,Jorge I. Gamez-Nava,Edsaúl Emilio Pérez-Guerrero,José Francisco Muñoz-Valle +9 more
TL;DR: It is suggested that MIF can induce a differential inflammatory response in physiological and pathological conditions with a predominance of a Th17 cytokine profile inPBMC from HS and an increase in TNF-α and IL-6 expression in PBMC from active SLE patients.
Journal ArticleDOI
MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.
Akinobu Ochi,Dong Chen,Wibke Schulte,Lin Leng,Nickolas Gilbert Moeckel,Marta Piecychna,Luisa Averdunk,Luisa Averdunk,Christian Stoppe,Richard Bucala,Gilbert W. Moeckel +10 more
TL;DR: Results indicate that MIF-2/D-DT is an important factor in tubular cell regeneration and may be of therapeutic utility as a regenerative agent in the clinical setting of ischemic acute kidney injury.