R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
Papers
More filters
Journal ArticleDOI
Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end products
TL;DR: It is proposed that the inability of LDL modified by AGEs to bind to the LDLr is caused by modification of residues adjacent to the putative LDLr-binding site that were undetected by previous immunochemical studies.
Book ChapterDOI
Advanced glycation end products: detection and reversal.
TL;DR: This chapter describes the present state of methodology for the detection of advanced glycation end-products (AGEs) and discusses the experimental application of a new class of pharmacological agents capable of chemically dissociating AGE cross-links and physically “breaking” the covalent bond linking two polypeptide chains.
Journal ArticleDOI
The reaction of 16α‐hydroxyestrone with erythrocytes in vitro and in vivo
TL;DR: The accumulation of 16αOHE-proteins may contribute to the understanding of systemic lupus erythematosus, an autoimmune disease in which elevated levels of 16β-Hydroxyestrone occur, and the amount of these adducts was quantitated by radioimmunoassy and found to be five times higher than the plasma levels of free 16 αOHE.
Journal ArticleDOI
Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis
Xueyan Peng,Susan K. Mathai,Lynne Murray,Thomas Russell,Ronald Reilkoff,Qingsheng Chen,Mridu Gulati,Jack A. Elias,Richard Bucala,Ye Gan,Erica L. Herzog +10 more
TL;DR: Interventions that prevent collagen production by monocytes via modulation of caspase activation and of apoptosis may be ameliorative in monocyte-associated, TGF-β1-driven processes such as pulmonary fibrosis.
Journal ArticleDOI
Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus.
TL;DR: Evidence is provided that the LupusQoL-China is valid as a disease-specific HRQo lupus erythematosus assessment tool for Chinese patients with SLE.