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Richard Bucala

Researcher at Yale University

Publications -  622
Citations -  58697

Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.

Papers
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Journal ArticleDOI

Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein

Yousef Al-Abed, +3 more
- 09 Feb 1996 - 
TL;DR: Data support the concept that AGE formation in close proximity to unsaturated fatty acyl groups leads to lipid oxidation and provide additional evidence that advanced glycosylation is an important pathogenic modification of the LDL particle in vivo.
Journal ArticleDOI

Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.

Georgios Pantouris, +11 more
- 11 Jun 2018 - 
TL;DR: Dynamical correlation between a residue located at the opening of one end of the MIF solvent channel, previously thought to be a consequence of homotrimerization, and residues in a distal region responsible for CD74 activation are revealed.
Journal ArticleDOI

Predicted structure of MIF/CD74 and RTL1000/CD74 complexes

Roberto Meza-Romero, +4 more
- 06 Feb 2016 - 
TL;DR: Structural modeling predicts a new MIF(CD74)3 dodecamer that may provide the basis for increased MIF potency and the requirement for ~3-fold excess RTL1000 to achieve full antagonism.
Journal ArticleDOI

What Is the Significance of Perioperative Release of Macrophage Migration Inhibitory Factor in Cardiac Surgery

Christian Stoppe, +13 more
- 20 Jul 2013 - 
TL;DR: The role of MIF increase during cardiac surgery in response to oxidative stress is highlighted and it is hypothesized that intraoperative MIF secretion is due to I/R and enhances the antioxidant capacity in patients during heart surgery.
Patent

Compounds having mif antagonist activity

Yousef Al-Abed, +3 more
TL;DR: A genus of optionally substituted Schiff base condensation products (and the carba analogs thereof) comprising an amino acid component and a benzaldehyde component, that have MIF (macrophage migration inhibitory factor) antagonist activity was disclosed in this article.