R
Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice
Cecilie Bay-Richter,Shorena Janelidze,Analise Sauro,Richard Bucala,Jack W. Lipton,Tomas Deierborg,Lena Brundin,Lena Brundin +7 more
TL;DR: The findings support that MIF is involved in the generation of depressive-like symptoms, potentially by the effects of IFN-γ on dopamine metabolism and further suggests a sex-specific regulation of the involved mechanisms.
Journal ArticleDOI
Interferon-gamma induces macrophage migration inhibitory factor synthesis and secretion by tubular epithelial cells.
Edwina K Rice,David J. Nikolic-Paterson,Prudence A. Hill,Christine N. Metz,Richard Bucala,Robert C. Atkins,Gregory H Tesch +6 more
TL;DR: Findings indicate that IFN‐γ induces rapid secretion of MIF by tubular epithelial cells, and suggest that this may be an important mechanism leading to inflammatory cell accumulation and activation during kidney disease.
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Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis.
Corinna Schmitz,Corinna Schmitz,Heidi Noels,Omar El Bounkari,Eva Straussfeld,Eva Straussfeld,Remco T. A. Megens,Marieke Sternkopf,Setareh Alampour-Rajabi,Christine Krammer,Pathricia V. Tilstam,Pathricia V. Tilstam,Norbert Gerdes,Christina Bürger,Aphrodite Kapurniotu,Richard Bucala,Joachim Jankowski,Christian Weber,Juergen Bernhagen +18 more
TL;DR: The atherosclerotic phenotype of Mif‐gene deletion in Apoe−/− mice is investigated and a novel link between MIF and B cells in atherogenesis is revealed, associated with enhanced B‐cell hypersensitivity, which in global but not BM‐restricted Mif deficiency favors an atheroprotective autoantibody profile in atherosclerosis.
Journal Article
Polyclonal activation of B lymphocytes by lipopolysaccharide requires macrophage-derived interleukin-1
TL;DR: B-cell activation by LPS was found to be strictly dependent on the presence of adherent macrophages, and antibody neutralization and cytokine reconstitution studies demonstrated that macrophage-derived interleukin- (IL-1) is a necessary co-factor for LPS-induced polyclonal activation.
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Increased Levels of 16α-Hydroxyestrone-Modified Proteins in Pregnancy and in Systemic Lupus Erythematosus
TL;DR: Measurements of the level of 16 alpha OHE-lysine present within proteins of varying half-lives obtained from normal subjects, patients with systemic lupus erythematosus, and pregnant women provide a useful indicator of the long term 16alpha OHE status of an individual.