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Richard Bucala
Researcher at Yale University
Publications - 622
Citations - 58697
Richard Bucala is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 119, co-authored 595 publications receiving 54607 citations. Previous affiliations of Richard Bucala include École Polytechnique Fédérale de Lausanne & Rockefeller University.
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Journal ArticleDOI
Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly.
Feng Qian,Xiaomei Wang,Lin Zhang,Shu Chen,Marta Piecychna,Heather G. Allore,Linda K. Bockenstedt,Stephen E. Malawista,Richard Bucala,Albert C. Shaw,Erol Fikrig,Erol Fikrig,Ruth R. Montgomery +12 more
TL;DR: A multivariable mixed effect model is used to report a highly significant increase in TLR5‐induced production of IL‐8 from monocytes of older individuals, which may provide a critical mechanism to enhance immune responsiveness in older individuals.
Journal Article
De novo renal expression of macrophage migration inhibitory factor during the development of rat crescentic glomerulonephritis
Hui Y. Lan,Wei Mu,Niansheng Yang,Andreas Meinhardt,David J. Nikolic-Paterson,Yee Yung Ng,Michael Bacher,Robert C. Atkins,Richard Bucala +8 more
TL;DR: Data provide the first demonstration that renal epithelial cells are a major source of MIF in both normal and diseased kidney and the up-regulation of Mif expression may play an important role in macrophage accumulation and progressive renal injury in rat crescentic glomerulonephritis.
Journal ArticleDOI
Evolving complexity of MIF signaling.
TL;DR: D-dopachrome tautomerase (D-DT or MIF-2) was recognized to be a structural and functional homolog of MIF, which could exert overlapping effects, raising further the complexity of canonical MIF signaling pathways.
Journal Article
Cloning and characterization of the gene for mouse macrophage migration inhibitory factor (mif)
Robert A. Mitchell,Michael Bacher,Jürgen Bernhagen,Tatyana Pushkarskaya,Michael F Seldin,Richard Bucala +5 more
TL;DR: The cloned mouse MIF gene is cloned and potential regulatory sequences present within the 5'-proximal promoter region are identified, including both inflammatory/growth factor-related elements and sites associated with the genes for certain peptide hormones.
Journal ArticleDOI
Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes
Barbara Sherry,Gabriele Zybarth,Massimo Alfano,Larisa Dubrovsky,Robert A. Mitchell,Daniel H. Rich,Peter C. Ulrich,Richard Bucala,Anthony Cerami,Michael Bukrinsky +9 more
TL;DR: It is reported that HIV-1 infection of primary peripheral blood mononuclear cells can be inhibited by an excess of exogenously added CyPA; a CsA analogue unable to enter the cells; and neutralizing antibodies to CyPA.