T
Takeo Yoshikawa
Researcher at RIKEN Brain Science Institute
Publications - 294
Citations - 13261
Takeo Yoshikawa is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Single-nucleotide polymorphism & Bipolar disorder. The author has an hindex of 57, co-authored 263 publications receiving 12000 citations. Previous affiliations of Takeo Yoshikawa include Tokyo Medical and Dental University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake,Yuko Nakabayashi,Yuko Nakabayashi,Ikuko Mizuta,Ikuko Mizuta,Yushi Hirota,Yushi Hirota,Chiyomi Ito,Chiyomi Ito,Michiaki Kubo,Takahisa Kawaguchi,Tatsuhiko Tsunoda,Masahiko Watanabe,Atsushi Takeda,Hiroyuki Tomiyama,Kenji Nakashima,Kazuko Hasegawa,Fumiya Obata,Takeo Yoshikawa,Hideshi Kawakami,Saburo Sakoda,Mitsutoshi Yamamoto,Nobutaka Hattori,Miho Murata,Yusuke Nakamura,Tatsushi Toda,Tatsushi Toda +26 more
TL;DR: The results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD.
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Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.
Ricardo Segurado,Sevilla D. Detera-Wadleigh,Douglas F. Levinson,Cathryn M. Lewis,Michael Gill,John I. Nurnberger,Nicholas John Craddock,J. Raymond DePaulo,Miron Baron,Elliot S. Gershon,Jenny Ekholm,Sven Cichon,Gustavo Turecki,Stephan Claes,John R. Kelsoe,Peter R. Schofield,Renee F. Badenhop,Renee F. Badenhop,Jean Morissette,Hilary Coon,Douglas Blackwood,L. Alison McInnes,Tatiana Foroud,Howard J. Edenberg,Theodore Reich,John P. Rice,Alison Goate,Melvin G. McInnis,Francis J. McMahon,Judith A. Badner,Lynn R. Goldin,Phil Bennett,Virginia L. Willour,Peter P. Zandi,Jianjun Liu,Conrad T. Gilliam,S H Juo,Wade H. Berrettini,Takeo Yoshikawa,Leena Peltonen,Leena Peltonen,Jouko Lönnqvist,Markus M. Nöthen,Johannes Schumacher,Christine Windemuth,Marcella Rietschel,Peter Propping,Wolfgang Maier,Martin Alda,Paul Grof,Guy A. Rouleau,Jurgen Del-Favero,Christine Van Broeckhoven,Julien Mendlewicz,Rolf Adolfsson,M. Anne Spence,Hermann Luebbert,L. J. Adams,Jennifer A. Donald,Philip B. Mitchell,Nicholas Barden,Eric Shink,William Byerley,Walter J. Muir,Peter M. Visscher,Stuart MacGregor,Hugh Gurling,Gursharan Kalsi,Andrew McQuillin,Michael Escamilla,Victor I. Reus,Pedro León,Nelson B. Freimer,Henrik Ewald,Torben A Kruse,Ole Mors,Uppala Radhakrishna,Jean-Louis Blouin,Stylianos E. Antonarakis,Nurten A. Akarsu +79 more
TL;DR: The present results for the very narrow model are promising but suggest that more and larger data sets are needed to support linkage, as well as suggest that linkage might be detected in certain populations or subsets of pedigrees.
Journal ArticleDOI
O1-7-4-1Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake,Ikuko Mizuta,Michiaki Kubo,Takahisa Kawaguchi,Tatsuhiko Tsunoda,Takeo Yoshikawa,Saburo Sakoda,Mitsutoshi Yamamoto,Nobutaka Hattori,Miho Murata,Yusuke Nakamura,Tatsushi Toda +11 more
TL;DR: Clinical and genetic information of 5 Japanese patients with Bardet-Biedl syndrome is summarized and it is found that rare liver fibrosis was detected in two patients, while only two patients had renal dysfunction, thought to be a universal symptom.
Journal ArticleDOI
A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2
Sevilla D. Detera-Wadleigh,Judith A. Badner,Judith A. Badner,Wade H. Berrettini,Takeo Yoshikawa,Lynn R. Goldin,Gordon Turner,D. Y. Rollins,Tracy Moses,Alan R. Sanders,Alan R. Sanders,Jayaprakash D. Karkera,Lisa E. Esterling,Jin Zeng,Thomas N. Ferraro,Juliet J. Guroff,Diane Kazuba,M. E. Maxwell,John I. Nurnberger,Elliot S. Gershon,Elliot S. Gershon +20 more
TL;DR: By comprehensive screening of the entire genome, a genome-wide scan is conducted on approximately 396 individuals from 22 multiplex pedigrees by using 607 microsatellite markers to detect unreported loci for bipolar disorder, found support for proposed linkages, and gained evidence for the overlap of susceptibility regions for bipolar Disorder and schizophrenia.
Journal ArticleDOI
Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia
Miki Bundo,Manabu Toyoshima,Yohei Okada,Wado Akamatsu,Junko Ueda,Taeko Nemoto-Miyauchi,Fumiko Sunaga,Michihiro Toritsuka,Daisuke Ikawa,Akiyoshi Kakita,Motoichiro Kato,Kiyoto Kasai,Toshifumi Kishimoto,Hiroyuki Nawa,Hideyuki Okano,Takeo Yoshikawa,Tadafumi Kato,Kazuya Iwamoto,Kazuya Iwamoto +18 more
TL;DR: High L1 copy number in schizophrenia was demonstrated in neurons from prefrontal cortex of patients and in induced pluripotent stem (iPS) cell-derived neurons containing 22q11 deletions, suggesting hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia.