Y
Yu Wang
Researcher at Vanderbilt University Medical Center
Publications - 60
Citations - 6836
Yu Wang is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Gene & Population. The author has an hindex of 24, co-authored 49 publications receiving 5248 citations. Previous affiliations of Yu Wang include Vanderbilt University & Zhejiang University.
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Journal ArticleDOI
The Sorghum bicolor genome and the diversification of grasses
Andrew H. Paterson,John E. Bowers,Rémy Bruggmann,Inna Dubchak,Jane Grimwood,Heidrun Gundlach,Georg Haberer,Uffe Hellsten,Therese Mitros,Alexander Poliakov,Jeremy Schmutz,Manuel Spannagl,Haibao Tang,Xiyin Wang,Xiyin Wang,Thomas Wicker,Arvind K. Bharti,Jarrod Chapman,F. Alex Feltus,F. Alex Feltus,Udo Gowik,Igor V. Grigoriev,Eric Lyons,Christopher G. Maher,Mihaela Martis,Apurva Narechania,Robert Otillar,Bryan W. Penning,Asaf Salamov,Yu Wang,Lifang Zhang,Nicholas C. Carpita,Michael Freeling,Alan R. Gingle,C. Thomas Hash,Beat Keller,Patricia E. Klein,Stephen Kresovich,Maureen C. McCann,Ray Ming,Daniel G. Peterson,Daniel G. Peterson,Mehboob-ur-Rahman,Mehboob-ur-Rahman,Doreen Ware,Doreen Ware,Peter Westhoff,Klaus F. X. Mayer,Joachim Messing,Daniel S. Rokhsar,Daniel S. Rokhsar +50 more
TL;DR: An initial analysis of the ∼730-megabase Sorghum bicolor (L.) Moench genome is presented, placing ∼98% of genes in their chromosomal context using whole-genome shotgun sequence validated by genetic, physical and syntenic information.
The UK10K project identifies rare variants in health and disease
Klaudia Walter,Josine L. Min,Jie Huang,Lucy Crooks,Yasin Memari,Shane A. McCarthy,John R. B. Perry,ChangJiang Xu,Marta Futema,Daniel Lawson,Valentina Iotchkova,Stephan Schiffels,Audrey E. Hendricks,Petr Danecek,Rui Li,James A B Floyd,Louise V. Wain,Inês Barroso,Steve E. Humphries,Matthew E. Hurles,Eleftheria Zeggini,Jeffrey C. Barrett,Vincent Plagnol,J. Brent Richards,Celia M. T. Greenwood,Nicholas J. Timpson,Richard Durbin,Nicole Soranzo,Senduran Bala,Peter Clapham,Guy Coates,Tony Cox,Allan Daly,Yuanping Du,Sarah Edkins,Peter R. Ellis,Paul Flicek,Xiaosen Guo,Xueqin Guo,Liren Huang,David K. Jackson,Christopher J. Joyce,Thomas Keane,Anja Kolb-Kokocinski,Cordelia Langford,Yingrui Li,Jieqin Liang,Hong Lin,Ryan Liu,John Maslen,Dawn Muddyman,Michael A. Quail,Jim Stalker,Jianping Sun,Jing Tian,Guangbiao Wang,Jun Wang,Yu Wang,Kim Wong,Pingbo Zhang,Ewan Birney,Chris Boustred,Lu Chen,Gail Clement,Massimiliano Cocca,George Davey Smith,Ian N.M. Day,Aaron G. Day-Williams,Thomas A. Down,Ian Dunham,David M. Evans,Tom R. Gaunt,Matthias Geihs,Deborah J. Hart,Bryan Howie,Tim Hubbard,Pirro G. Hysi,Yalda Jamshidi,Konrad J. Karczewski,John P. Kemp,Genevieve Lachance,Monkol Lek,Margarida C. Lopes,Daniel G. MacArthur,Jonathan Marchini,Massimo Mangino,Iain Mathieson,Sarah Metrustry,Alireza Moayyeri,Kate Northstone,Kalliope Panoutsopoulou,Lavinia Paternoster,Lydia Quaye,Susan M. Ring,Graham R. S. Ritchie,Hashem A. Shihab,So-Youn Shin,Kerrin S. Small,María Soler Artigas,Lorraine Southam,Tim D. Spector,Beate St Pourcain,Gabriela L. Surdulescu,Ioanna Tachmazidou,Martin D. Tobin,Ana M. Valdes,Peter M. Visscher,Kirsten J. Ward,Scott Wilson,Jian Yang,Feng Zhang,Hou-Feng Zheng,Richard Anney,Muhammad Ayub,Douglas Blackwood,Patrick Bolton,Gerome Breen,David A. Collier,Nicholas John Craddock,Sarah Curran,David Curtis,Louise Gallagher,Daniel H. Geschwind,Hugh Gurling,Peter Holmans,Irene Lee,Jouko Lönnqvist,Peter McGuffin,Andrew M. McIntosh,Andrew McKechanie,Andrew McQuillin,James Morris,Michael Conlon O'Donovan,Michael John Owen,Aarno Palotie,Jeremy R. Parr,Tiina Paunio,Olli Pietiläinen,Karola Rehnström,Sally I. Sharp,David Skuse,David St Clair,Jaana Suvisaari,James T.R. Walters,Hywel Williams,Elena G. Bochukova,Rebecca Bounds,Anna F. Dominiczak,I. Sadaf Farooqi,Julia M. Keogh,Gaëlle Marenne,Andrew D. Morris,Stephen O'Rahilly,David J. Porteous,Blair H. Smith,Eleanor Wheeler,Saeed Al Turki,Carl A. Anderson,Dinu Antony,PL Beales,Jamie Bentham,Shoumo Bhattacharya,Mattia Calissano,Keren J. Carss,Krishna Chatterjee,Sebahattin Cirak,Catherine Cosgrove,David R. FitzPatrick,A. Reghan Foley,Christopher S. Franklin,Detelina Grozeva,Hannah M. Mitchison,Francesco Muntoni,Alexandros Onoufriadis,Victoria E. R. Parker,Felicity Payne,F. Lucy Raymond,Nicola D. Roberts,David B. Savage,Peter J. Scambler,Miriam Schmidts,Nadia Schoenmakers,Robert K. Semple,Eva Goncalves Serra,Olivera Spasic-Boskovic,Elizabeth Stevens,Margriet van Kogelenberg,Parthiban Vijayarangakannan,Kathleen A. Williamson,Crispian Wilson,Tamieka Whyte,Antonio Ciampi,Karim Oualkacha,Martin Bobrow,Heather Griffin,Jane Kaye,Karen Kennedy,Alastair Kent,Carol Smee,R. Charlton,Rosemary Ekong,Farrah Khawaja,Luis R. Lopes,Nicola Migone,Stewart J. Payne,Rebecca C. Pollitt,Sue Povey,Cheryl K. Ridout,Rachel L. Robinson,Richard H Scott,Adam Shaw,Petros Syrris,Rohan Taylor,Anthony M. Vandersteen,Antoinette Amuzu,Juan P. Casas,John C. Chambers,George Dedoussis,Giovanni Gambaro,Paolo Gasparini,Aaron Isaacs,Jon Johnson,Marcus E. Kleber,Jaspal S. Kooner,Claudia Langenberg,Jian'an Luan,Giovanni Malerba,Winfried Maerz,Angela Matchan,Richard W Morris,Børge G. Nordestgaard,Marianne Benn,Robert A. Scott,Daniela Toniolo,Michela Traglia,Anne Tybjærg-Hansen,Cornelia M. van Duijn,Elisabeth M. van Leeuwen,Anette Varbo,Peter H. Whincup,Gianluigi Zaza,Weihua Zhang +241 more
TL;DR: The contribution of rare and low-frequency variants to human traits is largely unexplored as mentioned in this paper, but the contribution of these variants to the human traits has not yet been fully explored.
Journal ArticleDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Thomas P. Brouwer,Douglas B. Johnson,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula Ericsson-Gonzalez,Pornpimol Charoentong,Pornpimol Charoentong,Justin M. Balko,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +25 more
TL;DR: QuanTIseq as discussed by the authors is a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data, which is extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
Posted ContentDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula I. Ericsson-Gonzalez,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +20 more
TL;DR: QuanTIseq, a deconvolution method that quantifies the densities of ten immune cell types from bulk RNA sequencing data and tissue imaging data, is developed and used to show how kinase inhibitors modulate the immune contexture and suggest that it might have predictive value for immunotherapy.
Journal ArticleDOI
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Ayush Giri,Jacklyn N. Hellwege,Jacob M. Keaton,Jacob M. Keaton,Jihwan Park,Chengxiang Qiu,Helen R. Warren,Helen R. Warren,Eric S. Torstenson,Eric S. Torstenson,Csaba P. Kovesdy,Yan V. Sun,Otis D. Wilson,Otis D. Wilson,Cassianne Robinson-Cohen,Christianne L. Roumie,Cecilia P. Chung,K A Birdwell,K A Birdwell,Scott M. Damrauer,Scott L. DuVall,Derek Klarin,Kelly Cho,Yu Wang,Evangelos Evangelou,Evangelos Evangelou,Claudia P. Cabrera,Claudia P. Cabrera,Louise V. Wain,Louise V. Wain,Rojesh Shrestha,Brian S. Mautz,Elvis A. Akwo,Muralidharan Sargurupremraj,Stéphanie Debette,Michael Boehnke,Laura J. Scott,Jian'an Luan,Zhao J-H.,Sara M. Willems,Sébastien Thériault,Nabi Shah,Nabi Shah,Christopher Oldmeadow,Peter Almgren,Ruifang Li-Gao,Niek Verweij,Thibaud Boutin,Massimo Mangino,Massimo Mangino,Ioanna Ntalla,Elena V. Feofanova,Praveen Surendran,James P. Cook,Savita Karthikeyan,Najim Lahrouchi,Ching-Ti Liu,Nuno Sepúlveda,Tom G. Richardson,Aldi T. Kraja,Philippe Amouyel,Martin Farrall,Neil Poulter,Markku Laakso,Eleftheria Zeggini,Peter S. Sever,Robert A. Scott,Claudia Langenberg,Nicholas J. Wareham,David Conen,Palmer Cna.,John Attia,Daniel I. Chasman,Paul M. Ridker,Olle Melander,Dennis O. Mook-Kanamori,Harst Pvd.,Francesco Cucca,David Schlessinger,Caroline Hayward,Tim D. Spector,Jarvelin M-R.,Branwen J. Hennig,Branwen J. Hennig,Nicholas J. Timpson,Wei W-Q.,J C Smith,Yaomin Xu,Michael E. Matheny,E E Siew,C M Lindgren,C M Lindgren,C M Lindgren,Herzig K-H.,George Dedoussis,Josh C. Denny,Bruce M. Psaty,Howson Jmm.,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Mark J. Caulfield,Mark J. Caulfield,Paul Elliott,Paul Elliott,J M Gaziano,J M Gaziano,John Concato,Wilson Pwf.,Philip S. Tsao,D.R. Velez Edwards,D.R. Velez Edwards,Katalin Susztak,Christopher J. O'Donnell,Adriana M. Hung,Adriana M. Hung,Todd L. Edwards,Todd L. Edwards +117 more
TL;DR: Analysis of blood pressure data from the Million Veteran Program trans-ethnic cohort identifies common and rare variants, and genetically predicted gene expression across multiple tissues associated with systolic, diastolic and pulse pressure in over 775,000 individuals.