Institution
Aalto University
Education•Espoo, Finland•
About: Aalto University is a education organization based out in Espoo, Finland. It is known for research contribution in the topics: Computer science & Context (language use). The organization has 9969 authors who have published 32648 publications receiving 829626 citations. The organization is also known as: TKK & Aalto-korkeakoulu.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: A threshold size is demonstrated for the emergence of LSPR in gold nanoclusters protected by a thiolate monolayer enabling engineering of their properties for plasmonic applications and help to develop understanding of the effect of the molecular overlayer on plAsmonic properties of MPCs.
Abstract: Gold nanoclusters protected by a thiolate monolayer (MPC) are widely studied for their potential applications in site-specific bioconjugate labeling, sensing, drug delivery, and molecular electronics. Several MPCs with 1–2 nm metal cores are currently known to have a well-defined molecular structure, and they serve as an important link between molecularly dispersed gold and colloidal gold to understand the size-dependent electronic and optical properties. Here, we show by using an ab initio method together with atomistic models for experimentally observed thiolate-stabilized gold clusters how collective electronic excitations change when the gold core of the MPC grows from 1.5 to 2.0 nm. A strong localized surface plasmon resonance (LSPR) develops at 540 nm (2.3 eV) in a cluster with a 2.0 nm metal core. The protecting molecular layer enhances the LSPR, while in a smaller cluster with 1.5 nm gold core, the plasmon-like resonance at 540 nm is confined in the metal core by the molecular layer. Our results d...
243 citations
••
TL;DR: The coating of DNA origami nanostructures with virus capsid proteins for enhancing cellular delivery by 13-fold and could readily find applications not only in sophisticated drug delivery applications but also in organizing intracellular reactions by origami-based templates.
Abstract: DNA origami structures can be programmed into arbitrary shapes with nanometer scale precision, which opens up numerous attractive opportunities to engineer novel functional materials. One intriguing possibility is to use DNA origamis for fully tunable, targeted, and triggered drug delivery. In this work, we demonstrate the coating of DNA origami nanostructures with virus capsid proteins for enhancing cellular delivery. Our approach utilizes purified cowpea chlorotic mottle virus capsid proteins that can bind and self-assemble on the origami surface through electrostatic interactions and further pack the origami nanostructures inside the viral capsid. Confocal microscopy imaging and transfection studies with a human HEK293 cell line indicate that protein coating improves cellular attachment and delivery of origamis into the cells by 13-fold compared to bare DNA origamis. The presented method could readily find applications not only in sophisticated drug delivery applications but also in organizing intracel...
243 citations
••
TL;DR: TET2 and TET3 redundantly regulate Foxp3 stability, and their activity can be modulated by vitamin C.
Abstract: Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine and other oxidized methylcytosines, intermediates in DNA demethylation. In this study, we examine the role of TET proteins in regulating Foxp3, a transcription factor essential for the development and function of regulatory T cells (T reg cells), a distinct lineage of CD4(+) T cells that prevent autoimmunity and maintain immune homeostasis. We show that during T reg cell development in the thymus, TET proteins mediate the loss of 5mC in T reg cell-specific hypomethylated regions, including CNS1 and CNS2, intronic cis-regulatory elements in the Foxp3 locus. Similar to CNS2-deficient T reg cells, the stability of Foxp3 expression is markedly compromised in T reg cells from Tet2/Tet3 double-deficient mice. Vitamin C potentiates TET activity and acts through Tet2/Tet3 to increase the stability of Foxp3 expression in TGF-β-induced T reg cells. Our data suggest that targeting TET enzymes with small molecule activators such as vitamin C might increase induced T reg cell efficacy.
243 citations
••
TL;DR: It is shown that incident spectra can be computationally reconstructed from the different spectral response functions and measured photocurrents along the length of the nanowire, which is a practical step forward for the use of other light-sensitive nanomaterials for such ultra-miniaturized spectroscopy platforms.
Abstract: Spectrometers with ever-smaller footprints are sought after for a wide range of applications in which minimized size and weight are paramount, including emerging in situ characterization techniques. We report on an ultracompact microspectrometer design based on a single compositionally engineered nanowire. This platform is independent of the complex optical components or cavities that tend to constrain further miniaturization of current systems. We show that incident spectra can be computationally reconstructed from the different spectral response functions and measured photocurrents along the length of the nanowire. Our devices are capable of accurate, visible-range monochromatic and broadband light reconstruction, as well as spectral imaging from centimeter-scale focal planes down to lensless, single-cell-scale in situ mapping.
243 citations
••
TL;DR: These artefacts can be removed with apparent minimal impact on neural activity using ICA, allowing the study of TMS-evoked cortical network properties, and characteristic TEPs following motor cortex stimulation could be recovered from artefacts data, corroborating the reliability of ICA-based artefact correction.
243 citations
Authors
Showing all 10135 results
Name | H-index | Papers | Citations |
---|---|---|---|
John B. Goodenough | 151 | 1064 | 113741 |
Ashok Kumar | 151 | 5654 | 164086 |
Anne Lähteenmäki | 116 | 485 | 81977 |
Kalyanmoy Deb | 112 | 713 | 122802 |
Riitta Hari | 111 | 491 | 43873 |
Robin I. M. Dunbar | 111 | 586 | 47498 |
Andreas Richter | 110 | 769 | 48262 |
Mika Sillanpää | 96 | 1019 | 44260 |
Muhammad Farooq | 92 | 1341 | 37533 |
Ivo Babuška | 90 | 376 | 41465 |
Merja Penttilä | 87 | 303 | 22351 |
Andries Meijerink | 87 | 426 | 29335 |
T. Poutanen | 86 | 120 | 33158 |
Sajal K. Das | 85 | 1124 | 29785 |
Kalle Lyytinen | 84 | 426 | 27708 |