Celal Bayar University

About: Celal Bayar University is a education organization based out in Magnesia ad Sipylum, Turkey. It is known for research contribution in the topics: Population & Heat transfer. The organization has 2960 authors who have published 6024 publications receiving 100646 citations.

Development and Validation of an Analytical Methodology Based on Liquid Chromatography-Electrospray Tandem Mass Spectrometry for the Simultaneous Determination of Phenolic Compounds in Olive Leaf Extract.

Abstract: A simple method was validated for the analysis of 31 phenolic compounds using liquid chromatography-electrospray tandem mass spectrometry. Proposed method was successfully applied to the determination of phenolic compounds in an olive leaf extract and 24 compounds were analyzed quantitatively. Olive biophenols were extracted from olive leaves by using microwave-assisted extraction with acceptable recovery values between 78.1 and 108.7%. Good linearities were obtained with correlation coefficients over 0.9916 from calibration curves of the phenolic compounds. The limits of quantifications were from 0.14 to 3.2 μg g-1. Intra-day and inter-day precision studies indicated that the proposed method was repeatable. As a result, it was confirmed that the proposed method was highly reliable for determination of the phenolic species in olive leaf extracts.

Granuloma faciale with extrafacial lesions.

Abstract: s are invited for a 3-day symposium, Àdvances in Medical and Surgical Dermatology', to be held 79± December 2001 in New York, USA. Closing date for abstracts is 1 November, 2001. The timetable for the meeting is as follows: Friday December 7: Surgical meeting. Cutting edge lectures on all aspects of surgical and cosmetic dermatology: Saturday December 8: Live patient demonstrations of filler substances, Botox, laser treatments. Scientific meeting lectures by leaders in dermatological research. Prizes of $500, $250 and $100 will be awarded for the best three poster abstracts. Sunday December 9: Medical meeting. State-of-the-art lectures on psoriasis, atopic dermatitis, STDs, skin manifestations of HIV, topical immunomodulators, contact dermatitis. Reduced registration fee available for dermatologists outside of north America. Further information can be obtained from: http://www.mssm.edu/dermatology/symposium2001, or by contacting Donald Rudikoff MID, email: RNAhybrid(a)aol.com British Skin Foundation 2001 Awards: Call for Grant Applications The Trustees of the British Skin Foundation wish to announce that funding is again available for skin disease research. This year there are four categories of award as listed below. Applicants are asked to apply for funding from the category that they feel is most appropriate. The closing date is 17th September 2001. BSF Research Awards: Oneor 2-year project grants of up to £50,000 per annum. The BSF Fellowship: A grant of £40,000 to support a specialist registrar in dermatology through one year of research. Candidates should submit details of their proposed research and a C.V. in the manner described below. Selection will be by interview in late 2001. It is envisaged that the successful candidate will already hold an NTN or will have just completed their training. BSF Small Grant Awards: One-off payments of up to £10,000. May be used to purchase equipment or for less costly projects. BSF Studentship: A 3-year package, value £44,000, covering tuition fees, expenses and some consumables. If you wish to receive an application form for a British Skin Foundation grant, please contact the office, specifying the type of grant you are interested in at: British Skin Foundation, 19 Fitzroy Square, London WIT 6EH, U.K. Tel: 20 7383 0266; fax: 7388 5263. NEWS AND NOTICES 373

Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder

Abstract: This study assessed the diagnostic agreement and intra- and inter-observer reproducibility of the World Health Organization/International Society of Urologic Pathology Consensus Classification of Urothelial Neoplasms (1998 WHO/ISUP classification) and the 1973 WHO classification. A teaching set with 5 slides of each papillary neoplasm of low malignant potential, low-grade papillary carcinoma, high-grade papillary carcinoma, and a guideline, as well as a study set of 30 slides containing ten cases of each category, were sent to participants. Six pathologists expert in urological pathology reviewed the 30 slides of non-invasive papillary urothelial tumors in the study set. Diagnostic accuracy and reproducibility were evaluated using intra- and inter-rater techniques (kappa statistic). A moderate to substantial intra- and inter-observer reproducibility was achieved for both the 1998 WHO/ISUP and 1973 WHO classification. The results of the two classification systems were not different statistically (P>0.05). Reproducibility was lower in low-grade tumors for both classifications. The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management.

High hydrostatic pressure effects on mold flora, citrinin mycotoxin, hydroxytyrosol, oleuropein phenolics and antioxidant activity of black table olives

Abstract: High hydrostatic pressure (HHP) as a non-thermal technology is an effective tool for microbiologically safe and shelf-stable fruits. Mycotoxin citrinin (CIT) is a toxic secondary metabolite, especially produced from filamentous fungus Penicillium citrinum and is also produced by other species of Penicillium , Aspergillus , and Monascus that are able to develop on olive after harvest, during brine and storage of olives. Nutritional benefits of olive fruit are mainly related to phenolics such as hydroxytyrosol, oleuropein and antioxidative effects. With HHP application of olives, total mold was reduced to 90% at 25 °C whereas it was 100% at 4 °C based on Rose-Bengal Chloramphenicol Agar (RBCA). Total Aerobic-Mesofilic Bacteria load was reduced to 35–76% at 35 ± 2 °C based on the Plate Count Agar (PCA). Citrinin load was reduced to 64–100% at 35 ± 2 °C. 2.5; 10; 25; and 100 ppb of spiked citrinin in sample were degraded as %56; %37; %9; and %1.3, respectively. 2.5 ppb and less citrinin contamination in table olive were degraded more (56%). Total phenolics were increased to 2.1–2.5-fold after HHP (as mgGA/100 g). Hydroxytyrosol in olives increased on average 0.8–2.0-fold whereas oleuropein decreased on average 1–1.2-fold after HHP (as mg/kg dwt). Antioxidant activity values varied from 17.238 to 29.344 mmol Fe 2+ /100 g for control samples whereas 18.579–32.998 mmol Fe 2+ /100 g for HHP-treated samples. HHP could be used in the olive industry as non-thermal preservation.