Celal Bayar University

About: Celal Bayar University is a education organization based out in Magnesia ad Sipylum, Turkey. It is known for research contribution in the topics: Population & Heat transfer. The organization has 2960 authors who have published 6024 publications receiving 100646 citations.

The evaluation of eustachian tube function in patients with chronic otitis media.

Abstract: In this study we evaluated eustachian tube function in patients with chronic otitis media and compared the results with normal subjects. Two different eustachian tube function tests were applied to 60 ears of the chronic otitis media group and 146 ears of the control group. While eustachian tube dysfunction was observed in 71.7% of the chronic suppurative otitis media group, it was only seen in 34.9% of the control group.

Overcoming drug resistance in hormone- and drug-refractory prostate cancer cell line, PC-3 by docetaxel and gossypol combination

Abstract: Drug resistance is a significant challenge of daily oncology practice. Docetaxel and gossypol both have antitumoral activity in hormone-refractory prostate cancer (HRPC). Our results revealed that docetaxel and gossypol were synergistically cytotoxic and apoptotic in PC-3 cells in a dose- and time-dependent manner. We further investigated the expression profiles of genes involved in drug resistance and metabolism with a Human Cancer Drug Resistance and Metabolism PCR Array® (SuperArray). Six of the 84 genes that are known to regulate drug resistance, metabolism, cell cycle, DNA repair and oncogenesis were downregulated ≥3-fold change by the combination treatment. These results may be important in devising mechanism-based and targeted therapeutic strategies for prostate cancer, especially in devising combination therapy for drug resistant prostate cancers.

Helsinki by nature: The Nature Step to Respiratory Health

Abstract: The Nature Step to Respiratory Health was the overarching theme of the 12th General Meeting of the Global Alliance against Chronic Respiratory Diseases (GARD) in Helsinki, August 2018. New approaches are needed to improve respiratory health and reduce premature mortality of chronic diseases by 30% till 2030 (UN Sustainable Development Goals, SDGs). Planetary health is defined as the health of human civilization and the state of the natural systems on which it depends. Planetary health and human health are interconnected, and both need to be considered by individuals and governments while addressing several SDGs. The concept of the Nature Step has evolved from innovative research indicating, how changed lifestyle in urban surroundings reduces contact with biodiverse environments, impoverishes microbiota, affects immune regulation and increases risk of NCDs. The Nature Step calls for strengthening connections to nature. Physical activity in natural environments should be promoted, use of fresh vegetables, fruits and water increased, and consumption of sugary drinks, tobacco and alcohol restricted. Nature relatedness should be part of everyday life and especially emphasized in the care of children and the elderly. Taking “nature” to modern cities in a controlled way is possible but a challenge for urban planning, nature conservation, housing, traffic arrangements, energy production, and importantly for supplying and distributing food. Actions against the well-known respiratory risk factors, air pollution and smoking, should be taken simultaneously. In Finland and elsewhere in Europe, successful programmes have been implemented to reduce the burden of respiratory disorders and other NCDs. Unhealthy behaviour can be changed by well-coordinated actions involving all stakeholders. The growing public health concern caused by NCDs in urban surroundings cannot be solved by health care alone; a multidisciplinary approach is mandatory.

Examining the religious tourism potential of Manisa, Turkey with a marketing perspective

Abstract: Purpose – This paper aims to, by having a marketing perspective, assess the potential of Manisa for religious tourism and shed some light on the ways of increasing that potential and to add to the religious tourism literature and practice in general. Design/methodology/approach – A number of depth interviews were conducted with the experts of culture, tourism, religion and religious assets in Manisa. People and institutions regarding religious tourism were called, visited and asked for the names of right interviewees. As a result, a total of 14 interviews were arranged and successfully accomplished. In addition to depth interviews, top 15 most popular travel Web sites (www.ebizmba.com/articles/travel-websites) are examined for tourist and guide opinions toward Manisa’s religious sites and its surroundings. Findings – The findings indicate that Manisa has highly important religious monuments belonging to three major religions, including three of the seven churches mentioned in the Apocalypse section of the...