Institution
Charles University in Prague
Education•Prague, Czechia•
About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.
Topics: Population, Large Hadron Collider, Czech, Magnetization, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: The maximal rate of bone loss, as judged by radiogrammetry of the metacarpals and by dual-photon absorptiometry of the lumbar spine, coincided with the peak of the dissociation between urinary hydroxyproline excretion and/or plasma tartrate resistant acid phosphatase activity, indicating continuous imbalance of bone remodeling in the patients.
272 citations
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TL;DR: This multidisciplinary ESPNIC position statement guides professionals in the assessment and reassessment of the effectiveness of treatment interventions for pain, distress, inadequate sedation, withdrawal syndrome and delirium.
Abstract: Background
This position statement provides clinical recommendations for the assessment of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants and children. Admission to a neonatal or paediatric intensive care unit (NICU, PICU) exposes a child to a series of painful and stressful events. Accurate assessment of the presence of pain and non-pain-related distress (adequacy of sedation, iatrogenic withdrawal syndrome and delirium) is essential to good clinical management and to monitoring the effectiveness of interventions to relieve or prevent pain and distress in the individual patient.
271 citations
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TL;DR: In this article, a set of new routines for the XSPEC package for analyzing X-ray spectra of black-hole accretion disks are presented, which can be used also as a stand-alone and flexible code with the capability of handling time-resolved spectra in the regime of strong gravity.
Abstract: Accreting black holes are believed to emit X-rays, which then mediate information about strong gravity in the vicinity of the emission region. We report on a set of new routines for the XSPEC package for analyzing X-ray spectra of black-hole accretion disks. The new computational tool significantly extends the capabilities of the currently available fitting procedures that include the effects of strong gravity and allows one to systematically explore the constraints on more model parameters than previously possible (e.g., black-hole angular momentum). Moreover, axial symmetry of the disk intrinsic emissivity is not assumed, although it can be imposed to speed up the computations. The new routines can be used also as a stand-alone and flexible code with the capability of handling time-resolved spectra in the regime of strong gravity. We have used the new code to analyze the mean X-ray spectrum from the long XMM-Newton 2001 campaign of the Seyfert 1 galaxy MCG -6-30-15. Consistent with previous findings, we obtained a good fit to the broad Fe K line profile for a radial line intrinsic emissivity law in the disk that is not a simple power law, and for near maximal value of black hole angular momentum. However, equally good fits can be obtained also for small values of the black hole angular momentum. The code has been developed with the aim of allowing precise modeling of relativistic effects. Although we find that current data cannot constrain the parameters of black-hole/accretion disk system well, the code allows, for a given source or situation, detailed investigations of what features of the data future studies should be focused on in order to achieve the goal of uniquely isolating the parameters of such systems.
271 citations
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TL;DR: The experiments complemented by microscopic modeling reveal that the carrier relaxation is significantly slowed down as the photon energy is tuned to values below the optical-phonon frequency; however, owing to the presence of hot carriers, optical-Phonon emission is still the predominant relaxation process.
Abstract: We study the carrier dynamics in epitaxially grown graphene in the range of photon energies from 10 to 250 meV. The experiments complemented by microscopic modeling reveal that the carrier relaxation is significantly slowed down as the photon energy is tuned to values below the optical-phonon frequency; however, owing to the presence of hot carriers, optical-phonon emission is still the predominant relaxation process. For photon energies about twice the value of the Fermi energy, a transition from pump-induced transmission to pump-induced absorption occurs due to the interplay of interband and intraband processes.
271 citations
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Stanford University1, University of Florence2, University of Rome Tor Vergata3, Wayne State University4, Ohio University5, Shanmugha Arts, Science, Technology & Research Academy6, University of Glasgow7, Creighton University8, Southern Connecticut State University9, Nara Medical University10, National Technical University of Athens11, New York Medical College12, University of Illinois at Urbana–Champaign13, Charles University in Prague14, National Institutes of Health15, Purdue University16, Mayo Clinic17, Dalhousie University18, King George's Medical University19, Applied Science Private University20, Sunnybrook Health Sciences Centre21, Icahn School of Medicine at Mount Sinai22
TL;DR: Inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted.
270 citations
Authors
Showing all 32719 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Petersen | 178 | 1091 | 153067 |
P. Chang | 170 | 2154 | 151783 |
Vaclav Vrba | 141 | 1298 | 95671 |
Milos Lokajicek | 139 | 1511 | 98888 |
Christopher D. Manning | 138 | 499 | 147595 |
Yves Sirois | 137 | 1334 | 95714 |
Rupert Leitner | 136 | 1201 | 90597 |
Gerald M. Reaven | 133 | 799 | 80351 |
Roberto Sacchi | 132 | 1186 | 89012 |
S. Errede | 132 | 1481 | 98663 |
Mark Neubauer | 131 | 1252 | 89004 |
Peter Kodys | 131 | 1262 | 85267 |
Panos A Razis | 130 | 1287 | 90704 |
Vit Vorobel | 130 | 919 | 79444 |
Jehad Mousa | 130 | 1226 | 86564 |