Institution
Charles University in Prague
Education•Prague, Czechia•
About: Charles University in Prague is a education organization based out in Prague, Czechia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 32392 authors who have published 74435 publications receiving 1804208 citations.
Topics: Population, Large Hadron Collider, Czech, Magnetization, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: It is shown that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles, and Stimulation of the lytic PIN1 degradation is not a default effect for general downregulation of proteins from plasma membranes, but a specific mechanism to rapidly modulate the Auxin distribution in cytokinIn-mediated developmental processes.
278 citations
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TL;DR: This review addresses the recent developments and trends in tailoring the nature and local properties of active sites in zeolite-based catalysts, with a special focus on novel extra-large pore, layered, nanocrystalline, and hierarchical zeolites with enhanced pore accessibility.
Abstract: This review addresses the recent developments and trends in tailoring the nature and local properties of active sites in zeolite-based catalysts, with a special focus on novel extra-large pore, layered (2D), nanocrystalline, and hierarchical (mesoporous) zeolites with enhanced pore accessibility. In the first part of the review, we discuss the latest achievements in the bottom-up (direct synthesis) and top-down (post-synthesis) approaches for isomorphous substitution in zeolites enabling control over the type (Bronsted, Lewis, or both), amount, strength, and location of acid sites. The benefits in catalysis provided by such zeolites with tuned acidity and improved accessibility are shown for different acid-catalyzed reactions involving bulky molecules, as in the synthesis of fine chemicals and biomass transformations. The incorporation of metal species of different sizes (increasing from single atoms to clusters and to nanoparticles) in zeolites allows expanding the set of reactions catalyzed by these materials. The main preparation strategies for designing metal–zeolite catalysts, especially those offering control over the size of the metal species, and their catalytic behaviour in industrially relevant and emerging sustainable catalytic processes are dealt with in the second part of the review. Particular attention is paid to the stabilization of size-controlled small metal clusters and nanoparticles through their encapsulation in the voids of zeolite frameworks as well as to the dynamic behaviour of the metal species under reactive environments with important implications in catalysis. The need for using advanced operando spectroscopic and imaging tools to unveil the precise nature and functioning of the active sites in working zeolites is emphasized. The information gathered in this review is expected to provide guidance for developing more efficient zeolite-based catalysts for existing and new applications.
278 citations
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TL;DR: In this paper, the authors evaluated the activity of vandetanib plus docetaxel in patients with previously treated non-small-cell lung cancer (NSCLC).
Abstract: Purpose Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of vandetanib plus docetaxel was assessed in patients with previously treated non–small-cell lung cancer (NSCLC). Patients and Methods This two-part study comprised an open-label run-in phase and a double-blind randomized phase. Eligible patients had locally advanced or metastatic (stage IIIB/IV) NSCLC after failure of first-line platinum-based chemotherapy. The primary objective of the randomized phase was to prolong progression-free survival (PFS) in patients receiving vandetanib (100 or 300 mg/d) plus docetaxel (75 mg/m2 intravenous infusion every 21 days) versus placebo plus docetaxel. The study was designed to have more than 75% power to detect 50% prolongation at a one-sided significance level of P < .20. Secondary objectives included objective response rate, overall survival, safety and tolerability. Results In the randomized phase (n ...
277 citations
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Leipzig University1, Odense University Hospital2, Université libre de Bruxelles3, Universidade Federal do Estado do Rio de Janeiro4, University Health Network5, Nottingham University Hospitals NHS Trust6, Ege University7, Ankara University8, Université de Montréal9, Universidade Federal do Rio Grande do Sul10, Federal University of Rio de Janeiro11, Hannover Medical School12, University of Plymouth13, University of New South Wales14, Cairo University15, Örebro University16, Ain Shams University17, Dokuz Eylül University18, Karolinska University Hospital19, Federal University of São Paulo20, Carlos III Health Institute21, University of Copenhagen22, State University of Campinas23, University of São Paulo24, Medical University of Vienna25, Masaryk University26, University of Manitoba27, Istanbul University28, University of British Columbia29, Aalborg University30, Katholieke Universiteit Leuven31, University of Western Ontario32, University of Düsseldorf33, University of Zurich34, University of Calgary35, Geneva College36, Dalhousie University37, Queen Elizabeth II Health Sciences Centre38, Monash University39, University College London40, Goethe University Frankfurt41, University of St. Gallen42, Université catholique de Louvain43, Medical University of Graz44, University of Melbourne45, Charles University in Prague46, Ghent University Hospital47, Ghent University48, University of Hasselt49, Copenhagen University Hospital50, University of Antwerp51, Karolinska Institutet52
TL;DR: In most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use, and Diagnosis, treatment and transplant levels also differed considerably between countries.
Abstract: Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. For some countries, data from centralized registries were used to estimate diagnosis and treatment rates. Data for the number of liver transplants and the proportion attributable to HCV were obtained from centralized databases. Viremic prevalence estimates varied widely between countries, ranging from 0.3% in Austria, England and Germany to 8.5% in Egypt. The largest viremic populations were in Egypt, with 6,358,000 cases in 2008 and Brazil with 2,106,000 cases in 2007. The age distribution of cases differed between countries. In most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use. Diagnosis, treatment and transplant levels also differed considerably between countries. Reliable estimates characterizing HCV-infected populations are critical for addressing HCV-related morbidity and mortality. There is a need to quantify the burden of chronic HCV infection at the national level.
277 citations
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TL;DR: In this article, the e(+)e(-) pair continuum was measured in root s(NN) = 200 GeV Au+Au and p+p collisions over a wide range of mass and transverse momenta.
Abstract: PHENIX has measured the e(+)e(-) pair continuum in root s(NN) = 200 GeV Au+Au and p+p collisions over a wide range of mass and transverse momenta. The e(+)e(-) yield is compared to the expectations from hadronic sources, based on PHENIX measurements. In the intermediate-mass region, between the masses of the phi and the J/psi meson, the yield is consistent with expectations from correlated c (c) over bar production, although other mechanisms are not ruled out. In the low-mass region, below the phi, the p+p inclusive mass spectrum is well described by known contributions from light meson decays. In contrast, the Au+Au minimum bias inclusive mass spectrum in this region shows an enhancement by a factor of 4.7 +/- 0.4(stat) +/- 1.5(syst) +/- 0.9(model). At low mass (m(ee) < 0.3 GeV/c(2)) and high p(T) (1 < p(T) < 5 GeV/c) an enhanced e(+)e(-) pair yield is observed that is consistent with production of virtual direct photons. This excess is used to infer the yield of real direct photons. In central Au+Au collisions, the excess of the direct photon yield over the p+p is exponential in p(T), with inverse slope T = 221 +/- 19(stat) +/- 19(syst) MeV. Hydrodynamical models with initial temperatures ranging from T-init similar or equal to 300-600 MeV at times of 0.6-0.15 fm/c after the collision are in qualitative agreement with the direct photon data in Au+Au. For low p(T) < 1 GeV/c the low-mass region shows a further significant enhancement that increases with centrality and has an inverse slope of T similar or equal to 100 MeV. Theoretical models underpredict the low-mass, low-p(T) enhancement.
277 citations
Authors
Showing all 32719 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Petersen | 178 | 1091 | 153067 |
P. Chang | 170 | 2154 | 151783 |
Vaclav Vrba | 141 | 1298 | 95671 |
Milos Lokajicek | 139 | 1511 | 98888 |
Christopher D. Manning | 138 | 499 | 147595 |
Yves Sirois | 137 | 1334 | 95714 |
Rupert Leitner | 136 | 1201 | 90597 |
Gerald M. Reaven | 133 | 799 | 80351 |
Roberto Sacchi | 132 | 1186 | 89012 |
S. Errede | 132 | 1481 | 98663 |
Mark Neubauer | 131 | 1252 | 89004 |
Peter Kodys | 131 | 1262 | 85267 |
Panos A Razis | 130 | 1287 | 90704 |
Vit Vorobel | 130 | 919 | 79444 |
Jehad Mousa | 130 | 1226 | 86564 |