Institution
Forest Research Institute
Facility•Dehra Dūn, India•
About: Forest Research Institute is a facility organization based out in Dehra Dūn, India. It is known for research contribution in the topics: Population & Forest management. The organization has 5320 authors who have published 7625 publications receiving 185876 citations.
Topics: Population, Forest management, Picea abies, Forest ecology, Scots pine
Papers published on a yearly basis
Papers
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15 Apr 2008
98 citations
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TL;DR: This Phase II trial evaluated the efficacy, safety, and tolerability of cariprazine versus placebo in the treatment of acute manic or mixed episodes associated with bipolar I disorder.
Abstract: Objectives
Cariprazine, an orally active and potent dopamine D3 and D2 receptor partial agonist with preferential binding to D3 receptors, is being developed for the treatment of schizophrenia and bipolar mania. This Phase II trial evaluated the efficacy, safety, and tolerability of cariprazine versus placebo in the treatment of acute manic or mixed episodes associated with bipolar I disorder.
Methods
This was a multinational, randomized, double-blind, placebo-controlled, flexible-dose study of cariprazine 3–12 mg/day in patients with acute manic or mixed episodes associated with bipolar I disorder. Following washout, patients received three weeks of double-blind treatment. The primary and secondary efficacy parameters were change from baseline to Week 3 in Young Mania Rating Scale (YMRS) and Clinical Global Impressions–Severity (CGI-S) scores, respectively. Post-hoc analysis evaluated changes on YMRS single items.
Results
In each group, 118 patients received double-blind treatment; 61.9% of placebo and 63.6% of cariprazine patients completed the study. The overall mean daily dose of cariprazine was 8.8 mg/day. At Week 3, cariprazine significantly reduced YMRS and CGI-S scores versus placebo, with least square mean differences of −6.1 (p 10% for cariprazine) were extrapyramidal disorder, headache, akathisia, constipation, nausea, and dyspepsia. Changes in metabolic parameters were similar between groups, with the exception of fasting glucose; increases in glucose were significantly greater for cariprazine versus placebo (p < 0.05). Based on Barnes Akathisia Rating Scale and Simpson–Angus Scale scores, more cariprazine than placebo patients experienced treatment-emergent akathisia (cariprazine: 22%; placebo: 6%) or extrapyramidal symptoms (parkinsonism) (cariprazine: 16%; placebo: 1%).
Conclusion
Cariprazine demonstrated superior efficacy versus placebo and was generally well tolerated in patients experiencing acute manic or mixed episodes associated with bipolar I disorder.
98 citations
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TL;DR: In this paper, the effects of management on the second-rotation performance of Pinus radiata were investigated at three North Island sites, including: whole-tree harvest plus forest floor removal, whole tree harvest, and stem-only harvest retaining a single layer of slash.
98 citations
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TL;DR: Both maltose and glucose proved to be the effective carbon sources for polysaccharide production and the molecular weight of EPS from G. applanatum was also influenced by cultivation time, the longer the mycelia were cultivated, the higher the molecules of EPS formed.
98 citations
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TL;DR: The species of ophiostomatoid fungi associated with I. typographus japonicus in Japan are almost identical to those associated with the beetles infesting Norway spruce in Europe and this study improves the knowledge of the biogeography of the ophiobacterial fungi and the insects with which they are associated.
98 citations
Authors
Showing all 5332 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kari Alitalo | 174 | 817 | 114231 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Glenn D. Prestwich | 88 | 690 | 42758 |
John K. Volkman | 78 | 212 | 21931 |
Petri T. Kovanen | 77 | 432 | 27171 |
Hailong Wang | 69 | 647 | 19652 |
Mika Ala-Korpela | 65 | 319 | 18048 |
Heikki Henttonen | 64 | 271 | 14536 |
Zhihong Xu | 57 | 438 | 11832 |
Kari Pulkki | 54 | 215 | 11166 |
Louis A. Schipper | 53 | 192 | 9224 |
Sang Young Lee | 53 | 271 | 9917 |
Young-Joon Ahn | 52 | 288 | 9121 |
Venkatesh Narayanamurti | 49 | 258 | 9399 |
Francis M. Kelliher | 49 | 124 | 8599 |