Forest Research Institute

About: Forest Research Institute is a facility organization based out in Dehra Dūn, India. It is known for research contribution in the topics: Population & Forest management. The organization has 5320 authors who have published 7625 publications receiving 185876 citations.

Increased control of vegetation on global terrestrial energy fluxes

Abstract: Changes in vegetation structure are expected to influence the redistribution of heat and moisture; however, how variations in the leaf area index (LAI) affect this global energy partitioning is not yet quantified. Here, we estimate that a unit change in LAI leads to 3.66 ± 0.45 and −3.26 ± 0.41 W m−2 in latent (LE) and sensible (H) fluxes, respectively, over the 1982–2016 period. Analysis of an ensemble of data-driven products shows that these sensitivities increase by about 20% over the observational period, prominently in regions with a limited water supply, probably because of an increased transpiration/evaporation ratio. Global greening has caused a decrease in the Bowen ratio (B = H/LE) of −0.010 ± 0.002 per decade, which is attributable to the increased evaporative surface. Such a direct LAI effect on energy fluxes is largely modulated by plant functional types (PFTs) and background climate conditions. Land surface models (LSMs) misrepresent this vegetation control, possibly due to underestimation of the biophysical responses to changes in the water availability and poor representation of LAI dynamics. Changes in the leaf area index alter the distribution of heat and moisture. The change in energy partitioning related to leaf area, increasing latent and decreasing sensible fluxes over the observational period 1982–2016, is moderated by plant functional type and background climate.

Spatial interpolation of monthly mean climate data for China

Abstract: Spline interpolation techniques are used to develop a gridded climate database for China at a resolution of 0.01° in latitude and longitude. A digital elevation model (DEM) was developed at the same resolution to improve the accuracy of interpolation based upon the general spatial dependence of climate on topography. Climate data for the period 1971–2000 from meteorological stations in China were used to develop thin-plate smoothing spline surfaces for monthly mean temperature and precipitation. A regularly gridded climate database was produced by coupling the spline surfaces with the underlying DEM. The summary statistics show interpolation errors for monthly temperatures varying within 0.42–0.83 °C and 8–13% for monthly precipitation. These estimates are superior to results produced by methods commonly used in China. The fine-resolution spatial climate database has many potential applications in natural resource management. For example, it can be used as a baseline for climate change studies, in which potential distributions of flora and fauna can be predicted under the impact of climate change and priority areas for biodiversity conservation can be identified. Copyright  2005 Royal Meteorological Society.

Cariprazine in Acute Exacerbation of Schizophrenia: A Fixed-Dose, Phase 3, Randomized, Double-Blind, Placebo- And Active-Controlled Trial

Abstract: OBJECTIVE This phase 3 study evaluated the efficacy, safety, and tolerability of cariprazine in patients with acute exacerbation of schizophrenia. METHOD This multinational, randomized, double-blind, placebo- and active-controlled study was conducted from April 2010 to December 2011. Patients who met DSM-IV-TR criteria for schizophrenia were randomized to placebo (n = 153), cariprazine 3 mg/d (n = 155), cariprazine 6 mg/d (n = 157), or aripiprazole 10 mg/d (n = 152) for 6 weeks of double-blind treatment. The primary and secondary efficacy parameters were mean change from baseline to week 6 in Positive and Negative Syndrome Scale (PANSS) total score and Clinical Global Impressions-Severity of Illness (CGI-S) score, respectively. RESULTS Least squares mean differences (LSMDs) in PANSS total score change at week 6 significantly favored cariprazine 3 and 6 mg/d versus placebo (LSMD [95% CI]: 3 mg/d, -6.0 [-10.1 to -1.9], adjusted P = .0044; 6 mg/d, -8.8 [-12.9 to -4.7], adjusted P < .0001). Cariprazine 3 and 6 mg/d were also associated with significant improvements relative to placebo in CGI-S scores (LSMD [95% CI]: 3 mg/d, -0.4 [-0.6 to -0.2], adjusted P = .0044; 6 mg/d, -0.5 [-0.7 to -0.3], adjusted P < .0001). Significant differences from placebo were also observed with aripiprazole on the PANSS (LSMD [95% CI]: -7.0 [-11.0 to -2.9], P = .0008) and CGI-S (LSMD [95% CI]: -0.4 [-0.6 to -0.2], P = .0001). Common treatment-emergent adverse events (≥ 10%) were insomnia (all groups), akathisia (cariprazine 6 mg/d), and headache (placebo, cariprazine 6 mg/d). CONCLUSIONS This study supports the efficacy, safety, and tolerability of cariprazine 3 and 6 mg/d in the treatment of patients with acute exacerbation of schizophrenia. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT01104766.

Mast cells: multipotent local effector cells in atherothrombosis

Abstract: Our understanding of the relationship between the proatherogenic activities of arterial mast cells (MCs) and the development of atherosclerotic lesions is advancing. Atherosclerosis is a chronic inflammatory disease in which cholesterol and other lipids of circulating low-density lipoprotein (LDL) particles accumulate both extracellularly and intracellularly in the innermost layer of the arterial wall, the intima. One prerequisite for the proatherogenic activity of the LDL particles is their retention and proteolytic modification within the extracellular matrix of the intima. Experimental studies with activated chymase-secreting MCs have provided us fundamental insights into the molecular mechanisms of these processes. High-density lipoprotein (HDL) particles, again, remove cholesterol from the intracellular stores and carry it back to the circulation. MC chymase and tryptase actively degrade HDL and thus generate functionally defective particles that are unable to initiate cholesterol efflux from the arterial wall. In advanced atherosclerotic plaques, the accumulated lipids are separated from the circulation by a collagenous cap. By inducing apoptosis of endothelial cells (ECs), subendothelial MCs may induce detachment of ECs from the cap (plaque erosion). Moreover, MCs may weaken the cap if they disturb local collagen turnover by inducing apoptosis of the collagen-secreting smooth muscle cells or when they promote collagen degradation by activating matrix metalloproteinases. Plaques with a weak cap are vulnerable to rupture. The exposed subendothelial tissue at eroded and ruptured sites of plaques triggers local development of a platelet-rich thrombus. As regulators of the collagen-induced platelet activation and fibrin formation/fibrinolysis, the MCs may retard or accelerate the growth of the plaque-associated thrombus and ultimately participate in the wound-healing response of the injured plaque. We propose that by promoting cholesterol accumulation and plaque vulnerability and by locally regulating hemostasis, MCs in atherosclerotic lesions have the potential to contribute to the clinical outcomes of atherosclerosis, such as myocardial infarction and stroke.

Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD study

Abstract: Background Combining two long-acting bronchodilators with complementary mechanisms of action may provide treatment benefits to patients with chronic obstructive pulmonary disease (COPD) that are greater than those derived from either treatment alone. The efficacy and safety of a fixed-dose combination (FDC) of aclidinium bromide, a long-acting muscarinic antagonist, and formoterol fumarate, a long-acting β2-agonist, in patients with moderate to severe COPD are presented.