Institution
Harbin Institute of Technology
Education•Harbin, China•
About: Harbin Institute of Technology is a education organization based out in Harbin, China. It is known for research contribution in the topics: Microstructure & Control theory. The organization has 88259 authors who have published 109297 publications receiving 1603393 citations. The organization is also known as: HIT.
Topics: Microstructure, Control theory, Computer science, Alloy, Laser
Papers published on a yearly basis
Papers
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TL;DR: In this paper, a hierarchical porous carbons (HPC) was constructed from ant powder and a 3D framework comprised of interconnected macro-, meso-and micropores with suitable pore size distribution, together with an appropriate heteroatom doping of O, N and S.
495 citations
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TL;DR: The classification of hyperspectral images is a challenging task for a number of reasons, such as the presence of redundant features, the imbalance among the limited number of available training samples, and the high dimensionality of the data.
Abstract: Hyperspectral image classification has been a vibrant area of research in recent years. Given a set of observations, i.e., pixel vectors in a hyperspectral image, classification approaches try to allocate a unique label to each pixel vector. However, the classification of hyperspectral images is a challenging task for a number of reasons, such as the presence of redundant features, the imbalance among the limited number of available training samples, and the high dimensionality of the data.
493 citations
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TL;DR: Ferroptosis in cancer cells can be regulated by cadherin-mediated intercellular contacts, NF2–Hippo signalling, and activity of the YAP transcription co-activator, and this finding provides mechanistic insights into the observations that cancer cells with mesenchymal or metastatic property are highly sensitive to ferroPTosis.
Abstract: Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated in diseases such as ischaemic organ damage and cancer1,2. The enzyme glutathione peroxidase 4 (GPX4) is a central regulator of ferroptosis, and protects cells by neutralizing lipid peroxides, which are by-products of cellular metabolism. The direct inhibition of GPX4, or indirect inhibition by depletion of its substrate glutathione or the building blocks of glutathione (such as cysteine), can trigger ferroptosis3. Ferroptosis contributes to the antitumour function of several tumour suppressors such as p53, BAP1 and fumarase4–7. Counterintuitively, mesenchymal cancer cells—which are prone to metastasis, and often resistant to various treatments—are highly susceptible to ferroptosis8,9. Here we show that ferroptosis can be regulated non-cell-autonomously by cadherin-mediated intercellular interactions. In epithelial cells, such interactions mediated by E-cadherin suppress ferroptosis by activating the intracellular NF2 (also known as merlin) and Hippo signalling pathway. Antagonizing this signalling axis allows the proto-oncogenic transcriptional co-activator YAP to promote ferroptosis by upregulating several ferroptosis modulators, including ACSL4 and TFRC. This finding provides mechanistic insights into the observations that cancer cells with mesenchymal or metastatic property are highly sensitive to ferroptosis8. Notably, a similar mechanism also modulates ferroptosis in some non-epithelial cells. Finally, genetic inactivation of the tumour suppressor NF2, a frequent tumorigenic event in mesothelioma10,11, rendered cancer cells more sensitive to ferroptosis in an orthotopic mouse model of malignant mesothelioma. Our results demonstrate the role of intercellular interactions and intracellular NF2–YAP signalling in dictating ferroptotic death, and also suggest that malignant mutations in NF2–YAP signalling could predict the responsiveness of cancer cells to future ferroptosis-inducing therapies. Ferroptosis in cancer cells can be regulated by cadherin-mediated intercellular contacts, NF2–Hippo signalling, and activity of the YAP transcription co-activator.
492 citations
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Harbin Institute of Technology1, Chinese Academy of Sciences2, Harbin Engineering University3, RMIT University4, Yanshan University5, Shanghai Jiao Tong University6, Chongqing University7, Chinese Ministry of Education8, Nanchang University9, Tianjin University10, Taiyuan University of Technology11, Jilin University12
TL;DR: The first two China Youth Scholars Symposiums on Mg Alloys Research had been held at Harbin (2015) and Chongqing (2016) China, respectively, aiming to boost far-reaching initiatives for development of new Mg-based materials to satisfy the requirements for a broad range of industrial employments as mentioned in this paper.
488 citations
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TL;DR: In this article, a brief review on the use, theory and future perspectives of conventional, as well as novel materials towards heavy metal adsorption in wastewater treatment application is presented.
486 citations
Authors
Showing all 89023 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jiaguo Yu | 178 | 730 | 113300 |
Lei Jiang | 170 | 2244 | 135205 |
Gang Chen | 167 | 3372 | 149819 |
Xiang Zhang | 154 | 1733 | 117576 |
Hui-Ming Cheng | 147 | 880 | 111921 |
Yi Yang | 143 | 2456 | 92268 |
Bruce E. Logan | 140 | 591 | 77351 |
Bin Liu | 138 | 2181 | 87085 |
Peng Shi | 137 | 1371 | 65195 |
Hui Li | 135 | 2982 | 105903 |
Lei Zhang | 135 | 2240 | 99365 |
Jie Liu | 131 | 1531 | 68891 |
Lei Zhang | 130 | 2312 | 86950 |
Zhen Li | 127 | 1712 | 71351 |
Kurunthachalam Kannan | 126 | 820 | 59886 |