Institution
Mahidol University
Education•Bangkok, Nakhon Pathom, Thailand•
About: Mahidol University is a education organization based out in Bangkok, Nakhon Pathom, Thailand. It is known for research contribution in the topics: Population & Malaria. The organization has 23758 authors who have published 39761 publications receiving 878781 citations.
Topics: Population, Malaria, Plasmodium falciparum, Medicine, Plasmodium vivax
Papers published on a yearly basis
Papers
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TL;DR: The findings show that dengue vaccine is efficacious when given as three injections at months 0, 6, and 12 to children aged 2-14 years in endemic areas in Asia, and has a good safety profile.
812 citations
TL;DR: Parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide, according to evidence from Asia, and substantially reduces mortality in African children with severe malaria.
810 citations
TL;DR: A short course of twice-daily oral zidovudine was safe and well tolerated and, in the absence of breastfeeding, can lessen the risk for mother-to-child HIV-1 transmission by half.
804 citations
TL;DR: It is proposed that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.
Abstract: Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen in secondary infections is antibody-dependent enhancement (ADE) leading to increased replication in Fc receptor-bearing cells. In this study, we have generated a panel of human monoclonal antibodies to dengue virus. Antibodies to the structural precursor-membrane protein (prM) form a major component of the response. These antibodies are highly cross-reactive among the dengue virus serotypes and, even at high concentrations, do not neutralize infection but potently promote ADE. We propose that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.
801 citations
TL;DR: It is shown that increase in copy number of pfmdr1, a gene encoding a parasite transport protein, is the best overall predictor of treatment failure with mefloquine.
794 citations
Authors
Showing all 23819 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Nicholas J. White | 161 | 1352 | 104539 |
| Pete Smith | 156 | 2464 | 138819 |
| Randal J. Kaufman | 140 | 491 | 79527 |
| Kevin Marsh | 128 | 567 | 55356 |
| Barry M. Trost | 124 | 1635 | 79501 |
| John R. Perfect | 119 | 573 | 52325 |
| Jon Clardy | 116 | 983 | 56617 |
| François Nosten | 114 | 777 | 50823 |
| Paul Turner | 114 | 1099 | 61390 |
| Paul Kubes | 109 | 393 | 41022 |
| Ian M. Adcock | 107 | 660 | 42380 |
| Peter H. Verburg | 107 | 464 | 34254 |
| Guozhong Cao | 104 | 694 | 41625 |
| Carol L. Shields | 102 | 1424 | 46800 |
| Nicholas P. J. Day | 102 | 708 | 50588 |