Showing papers by "Moscow State University published in 2006"
TL;DR: Starting from chemical composition, USPEX is tested on numerous systems for which the stable structure is known and has observed a success rate of nearly 100%, simultaneously finding large sets of crystals.
960 citations
TL;DR: In this paper, the spectral regions used in the model were tuned in accordance with pigment of interest and the optical characteristics of the leaves studied, and showed that the developed technique allowed accurate estimation of total chlorophyll, carotenoids and anthocyanins, explaining more than 91%, 70% and 93% of pigment variation, respectively.
Abstract: [1] Leaf pigment content and composition provide important information about plant physiological status. Reflectance measurements offer a rapid, nondestructive technique to estimate pigment content. This paper describes a recently developed three-band conceptual model capable of remotely estimating total of chlorophylls, carotenoids and anthocyanins contents in leaves from many tree and crop species. We tuned the spectral regions used in the model in accord with pigment of interest and the optical characteristics of the leaves studied, and showed that the developed technique allowed accurate estimation of total chlorophylls, carotenoids and anthocyanins, explaining more than 91%, 70% and 93% of pigment variation, respectively. This new technique shows a great potential for noninvasive tracking of the physiological status of vegetation and the impact of environmental changes.
562 citations
TL;DR: The study identifies an RNA virus ExoN activity that is involved in the synthesis of multiple RNAs from the exceptionally large genomic RNA templates of CoVs.
Abstract: Replication of the giant RNA genome of severe acute respiratory syndrome (SARS) coronavirus (CoV) and synthesis of as many as eight subgenomic (sg) mRNAs are mediated by a viral replicase-transcriptase of outstanding complexity that includes an essential endoribonuclease activity. Here, we show that the CoV replicative machinery, unlike that of other RNA viruses, also uses an exoribonuclease (ExoN) activity, which is associated with nonstructural protein (nsp) 14. Bacterially expressed forms of SARS-CoV nsp14 were shown to act on both ssRNAs and dsRNAs in a 3′→5′ direction. The activity depended on residues that are conserved in the DEDD exonuclease superfamily. The protein did not hydrolyze DNA or ribose-2′-O-methylated RNA substrates and required divalent metal ions for activity. A range of 5′-labeled ssRNA substrates were processed to final products of ≈8–12 nucleotides. When part of dsRNA or in the presence of nonlabeled dsRNA, the 5′-labeled RNA substrates were processed to significantly smaller products, indicating that binding to dsRNA in cis or trans modulates the exonucleolytic activity of nsp14. Characterization of human CoV 229E ExoN active-site mutants revealed severe defects in viral RNA synthesis, and no viable virus could be recovered. Besides strongly reduced genome replication, specific defects in sg RNA synthesis, such as aberrant sizes of specific sg RNAs and changes in the molar ratios between individual sg RNA species, were observed. Taken together, the study identifies an RNA virus ExoN activity that is involved in the synthesis of multiple RNAs from the exceptionally large genomic RNA templates of CoVs.
545 citations
TL;DR: Experimental and theoretical studies of energy transfer in the photosynthetic light-harvesting complexes LH1, LH2, and LHCII performed during the past decade since the discovery of high-resolution structure are overviewed.
Abstract: We overview experimental and theoretical studies of energy transfer in the photosynthetic light-harvesting complexes LH1, LH2, and LHCII performed during the past decade since the discovery of high-resolution structure of these complexes. Experimental findings obtained with various spectroscopic techniques makes possible a modelling of the excitation dynamics at a quantitative level. The modified Redfield theory allows a precise assignment of the energy transfer pathways together with a direct visualization of the whole excitation dynamics where various regimes from a coherent motion of delocalized exciton to a hopping of localized excitations are superimposed. In a single complex it is possible to observe the switching between these regimes driven by slow conformational motion (as we demonstrate for LH2). Excitation dynamics under quenched conditions in higher-plant complexes is discussed.
444 citations
TL;DR: Element-element additions to unsaturated carbon-carbon bonds catalyzed by transition metal complexes and their applications in materials science and materials engineering are studied.
Abstract: Element-element additions to unsaturated carbon-carbon bonds catalyzed by transition metal complexes
440 citations
TL;DR: Nano–secondary ion mass spectrometry elemental maps reveal that amorphous iron oxide colloids adsorb Pu(IV) hydroxides or carbonates along with uranium carbonates, confirming that colloids are responsible for the long-distance transport of plutonium.
Abstract: Sorption of actinides, particularly plutonium, onto submicrometer-sized colloids increases their mobility, but these plutonium colloids are difficult to detect in the far-field. We identified actinides on colloids in the groundwater from the Mayak Production Association, Urals, Russia; at the source, the plutonium activity is ∼1000 becquerels per liter. Plutonium activities are still 0.16 becquerels per liter at a distance of 3 kilometers, where 70 to 90 mole percent of the plutonium is sorbed onto colloids, confirming that colloids are responsible for the long-distance transport of plutonium. Nano–secondary ion mass spectrometry elemental maps reveal that amorphous iron oxide colloids adsorb Pu(IV) hydroxides or carbonates along with uranium carbonates.
434 citations
TL;DR: The latest version of micromegas, a code that calculates the relic density of the lightest supersymmetric particle in the MSSM, is presented, with all tree-level processes for the annihilation of the LSP as well as all possible coannihilation processes with neutralinos, charginos, sleptons, squarks and gluinos.
430 citations
15 Sep 2006-Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment
TL;DR: The D0 experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996 as discussed by the authors, and the detector has been upgraded to take advantage of improvements to the Tevoton and to enhance its physics capabilities.
Abstract: The D0 experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996. Since then, the detector has been upgraded to take advantage of improvements to the Tevatron and to enhance its physics capabilities. We describe the new elements of the detector, including the silicon microstrip tracker, central fiber tracker, solenoidal magnet, preshower detectors, forward muon detector, and forward proton detector. The uranium/liquid-argon calorimeters and central muon detector, remaining from Run I, are discussed briefly. We also present the associated electronics, triggering, and data acquisition systems, along with the design and implementation of software specific to D0.
425 citations
Durham University1, University of Helsinki2, University of Wisconsin-Madison3, University of Rochester4, University of Catania5, Weizmann Institute of Science6, University of Warsaw7, University of Southampton8, CERN9, Lawrence Livermore National Laboratory10, Indian Institute of Science11, University of Montpellier12, Spanish National Research Council13, University of Zurich14, ETH Zurich15, Stanford University16, Northwestern University17, University of Pittsburgh18, Carleton University19, University of Hamburg20, Moscow State University21, University of Florida22, Paul Scherrer Institute23, University of Würzburg24, Imperial College London25, Florida State University26, University of Florence27, University of Bonn28, University at Buffalo29, RWTH Aachen University30, University of Sheffield31, University of California, Irvine32, Laboratoire d'Annecy-le-Vieux de physique des particules33, Brookhaven National Laboratory34, Argonne National Laboratory35, University of Bergen36, University of Mainz37, Centers for Medicare and Medicaid Services38, Lancaster University39, University of California, Santa Cruz40, University of Copenhagen41, University of Tokyo42, Austrian Academy of Sciences43, University of Manchester44, University College London45, University of Edinburgh46, University of California, Davis47, University of California, Berkeley48, University of Glasgow49, University of Barcelona50, Max Planck Society51, University of Chicago52, University of Turin53, Royal Holloway, University of London54, Kobe University55, University of Oslo56, Kyoto University57
TL;DR: In this paper, the authors discuss the possible interplay between the Large Hadron Collider (LHC) and the International e(+)e(-) Linear Collider (ILC) in testing the Standard Model and in discovering and determining the origin of new physics.
422 citations
TL;DR: This review covers the field of anion recognition from the perspective of tetrahedral oxyanion recognition by focusing on metal-free systems that are able to effect the recognition, binding or transport of phosphate and sulfate.
420 citations
TL;DR: The ability of pro-and eukaryotic microorganisms to synthesize growth-stimulating phytohormones is reviewed, with emphasis on the pathways of biosynthesis of these compounds and their effects on the physiological and biochemical properties of the producers.
Abstract: The ability of pro-and eukaryotic microorganisms to synthesize growth-stimulating phytohormones is reviewed, with emphasis on the pathways of biosynthesis of these compounds and their effects on the physiological and biochemical properties of the producers. Phytohormones are viewed as specific mediators in interactions between various organisms inhabiting the same ecological niche, the biological role of which is not limited to processes taking place in plants. In addition to setting forth the theoretical aspects of this problem, the review underscores the need to utilize such producer microorganisms in plant cultivation and biotechnology
TL;DR: In this review, interrelations between bioenergetic processes and such programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial suicide (mitoptosis) are summarized.
Abstract: In this review I summarize interrelations between bioenergetic processes and such programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial suicide (mitoptosis). The following conclusions are made. (I) ATP and rather often mitochondrial hyperpolarization (i.e. an increase in membrane potential, delta psi) are required for certain steps of apoptosis and necrosis. (II) Apoptosis, even if it is accompanied by delta psi and [ATP] increases at its early stage, finally results in a delta psi collapse and ATP decrease. (III) Moderate (about three-fold) lowering of [ATP] for short and long periods of time induces apoptosis and necrosis, respectively. In some types of apoptosis and necrosis, the cell death is mediated by a delta psi-dependent overproduction of ROS by the initial (Complex I) and the middle (Complex III) spans of the respiratory chain. ROS initiate mitoptosis which is postulated to rid the intracellular population of mitochondria from those that are ROS overproducing. Massive mitoptosis can result in cell death due to release to cytosol of the cell death proteins normally hidden in the mitochondrial intermembrane space.
TL;DR: A.P. Vinogradov and A.A.B. Ronov as mentioned in this paper showed that the principle of geochemical balance in the sedimentary process in application to Ca and carbonates appeared to be invalid and that the composition of the Earth's crust can also be evaluated based on data on the actual abundances of major magmatic, metamorphic and sedimentary rock types.
Abstract: The evaluation of the abundances of chemical elements in the Earth’s crust is a pivotal geochemical problem. Its first solutions in the early 20th century formed the empirical groundwork for geochemistry and justified concepts about the unity of the material of the Universe, the genesis of the chemical elements, and the geochemical differentiation of the Earth. The accumulation of newly obtained data called for the revision of this problem, and a series of papers by A.P. Vinogradov, which were published in Geokhimiya in 1956–1962, presented reevaluated contents of elements in the continental crust. In these papers, A.P. Vinogradov relied on the classic idea of the geochemical balance of the sedimentary process. These generalizations provided the foundation for the quantitative characterization of the geochemical background of the biosphere and allowed Vinogradov to formulate the principles of the melting and degassing of material in the outer Earth’s shells during the geologic history, a concept that became universally acknowledged in modern geochemistry and geology. The composition of the Earth’s crust can also be evaluated based not on the principle of geochemical balance in the sedimentary process but on data on the actual abundances of major magmatic, metamorphic, and sedimentary rock types. The possibility of this solution was provided after the extensive research of A.B. Ronov, who managed to develop a quantitative model for the structure of the Earth’s sedimentary shell. Based on these data, A.B. Ronov, A.A. Yaroshevsky, and A.A. Migdisov published a series of papers in Geokhimiya in 1967–1985 that presented a model for the chemical structure of the Earth’s crust with regard for the material composing not only the upper part of the continental crust but also its deep-seated granulite-basite layer and the oceanic crust. The quantitative estimates thus obtained led the authors to important conclusions: first, it was demonstrated that the estimated abundances of elements in the granite-metamorphic layer of the continental crust presented in the classic works by A.P. Vinogradov are confirmed by independent materials, which are based on data on the actual abundance of rocks. Second, incredible as it was, the principle of geochemical balance in the sedimentary process in application to Ca and carbonates appeared to be invalid. This problem remains unsettled as of yet and awaits its resolution.
TL;DR: In this article, the rescattering and energy loss of hard partons in ultrarelativistic heavy ion collisions has been simulated using a Monte Carlo tool introduced to modify a standard PYTHIA jet event.
Abstract: The method to simulate the rescattering and energy loss of hard partons in ultrarelativistic heavy ion collisions has been developed. The model is a fast Monte Carlo tool introduced to modify a standard PYTHIA jet event. The full heavy ion event is obtained as a superposition of a soft hydro-type state and hard multi-jets. The model is applied to the analysis of the jet quenching pattern at RHIC.
01 Jan 2006
TL;DR: The QGSJET model has been successfully used by different groups in the field of high energy cosmic rays as discussed by the authors, and the first general update of the model is devoted to the main improvement connected to an account for non-linear interaction effects which are of crucial importance for reliable model extrapolation into the ultra-high energy domain.
Abstract: Since a number of years the QGSJET model has been successfully used by different groups in the field of high energy cosmic rays. Current work is devoted to the first general update of the model. The key improvement is connected to an account for non-linear interaction effects which are of crucial importance for reliable model extrapolation into the ultra-high energy domain. The proposed formalism allows to obtain a consistent description of hadron-hadron cross sections and hadron structure functions and to treat non-linear effects explicitly in individual hadronic and nuclear collisions. Other ameliorations concern the treatment of low mass diffraction, employment of realistic nuclear density profiles, and re-calibration of model parameters using a wider set of accelerator data.
TL;DR: It is proposed that the specific NAD(P)H:oxygen superoxide (hydrogen peroxide) producing oxidoreductase(s) poised in equilibrium with NAD( P)H/NAD(P)+ couple should exist in the mitochondrial matrix, if mitochondria are, indeed, participate in ROS-controlled processes under physiologically relevant conditions.
TL;DR: All steps of eukaryotic translation in vitro are reconstituted using purified ribosomal subunits; initiation, elongation, and termination factors; and aminoacyl tRNAs to investigate termination using pretermination complexes assembled on mRNA encoding a tetrapeptide and to propose a model for translation termination that accounts for the cooperative action of eRF1 and eRF3 in ensuring fast release of nascent polypeptide.
TL;DR: Menning et al. as mentioned in this paper proposed a global Stratigraphic Reference Scale (GSS) for the analysis of the evolution of the Late Palaeozoic in the light of sedimentary geochemistry.
TL;DR: The SL(2, ℤ)-representation π on the center of the restricted quantum group at the primitive 2pth root of unity is shown to be equivalent to the SL( 2, ↦)-representations on the extended characters of the logarithmic (1, p) conformal field theory model in this article.
Abstract: The SL(2, ℤ)-representation π on the center of the restricted quantum group at the primitive 2pth root of unity is shown to be equivalent to the SL(2, ℤ)-representation on the extended characters of the logarithmic (1, p) conformal field theory model. The multiplicative Jordan decomposition of the ribbon element determines the decomposition of π into a ``pointwise'' product of two commuting SL(2, ℤ)-representations, one of which restricts to the Grothendieck ring; this restriction is equivalent to the SL(2, ℤ)-representation on the (1, p)-characters, related to the fusion algebra via a nonsemisimple Verlinde formula. The Grothendieck ring of at the primitive 2pth root of unity is shown to coincide with the fusion algebra of the (1, p) logarithmic conformal field theory model. As a by-product, we derive q-binomial identities implied by the fusion algebra realized in the center of .
TL;DR: Evidence is presented that dissolved HS are indeed taken up and interact directly and/or indirectly with freshwater organisms, and that they exert a mild chemical stress upon aquatic organisms in many ways.
Abstract: SUMMARY 1. This review focuses on direct and indirect interactions between dissolved humic substances (HS) and freshwater organisms and presents novel opinions and hypotheses on their ecological significance. Despite their abundance in freshwaters, the role of HS is still inadequately understood. These substances have been considered too large to be taken up by freshwater organisms. On the contrary, here we present evidence that dissolved HS are indeed taken up and interact directly and/or indirectly with freshwater organisms. 2. We show that dissolved HS exert a mild chemical stress upon aquatic organisms in many ways; they induce molecular chaperones (stress shock proteins), induce and modulate biotransformation enzymes and modulate (mainly inhibiting) the photosynthetic release of oxygen by freshwater plants. Furthermore, they produce an oxidative stress, which may lead to membrane oxidation. HS modulate the multixenobiotic resistance activity and probably other membrane-bound pumps. This property may lead to the increased bioaccumulation of xenobiotic chemicals. Furthermore, they can modulate the numbers of offspring in a nematode and feminise fish and amphibians. The ecological consequences of this potential remain obscure at present. HS also have the potential to act as chemical attractants (as shown with a nematode). 3. In some macrophytes and algae we show that HS interfere with photosynthesis and growth. For instance, the presence of HS suppresses cyanobacteria more than eukaryotic algae. By applying a quantitative structure activity relationship approach, we show that
TL;DR: Through overpressure experiments it was shown that both nonlinear propagation and cavitation mechanisms participate in accelerating lesion inception and growth, but no lesion displacement or distortion was observed in the absence of boiling.
Abstract: The importance of nonlinear acoustic wave propagation and ultrasound-induced cavitation in the acceleration of thermal lesion production by high intensity focused ultrasound was investigated experimentally and theoretically in a transparent protein-containing gel. A numerical model that accounted for nonlinear acoustic propagation was used to simulate experimental conditions. Various exposure regimes with equal total ultrasound energy but variable peak acoustic pressure were studied for single lesions and lesion stripes obtained by moving the transducer. Static overpressure was applied to suppress cavitation. Strong enhancement of lesion production was observed for high amplitude waves and was supported by modeling. Through overpressure experiments it was shown that both nonlinear propagation and cavitation mechanisms participate in accelerating lesion inception and growth. Using B-mode ultrasound, cavitation was observed at normal ambient pressure as weakly enhanced echogenicity in the focal region, but was not detected with overpressure. Formation of tadpole-shaped lesions, shifted toward the transducer, was always observed to be due to boiling. Boiling bubbles were visible in the gel and were evident as strongly echogenic regions in B-mode images. These experiments indicate that nonlinear propagation and cavitation accelerate heating, but no lesion displacement or distortion was observed in the absence of boiling.
TL;DR: In this article, the authors treated nonlinear effects in hadronic interactions by means of enhanced Pomeron diagrams and showed that the contribution of semihard processes to the interaction eikonal contains a significant nonfactorizable part.
Abstract: Nonlinear effects in hadronic interactions are treated by means of enhanced Pomeron diagrams, assuming that Pomeron-Pomeron coupling is dominated by soft partonic processes. It is shown that the approach allows to resolve a seeming contradiction between realistic parton momentum distributions, measured in deep inelastic scattering experiments, and the energy behavior of total proton-proton cross section. Also a general consistency with both soft and hard diffraction data is demonstrated. An important feature of the proposed scheme is that the contribution of semihard processes to the interaction eikonal contains a significant nonfactorizable part. On the other hand, the approach preserves the QCD factorization picture for inclusive high-${p}_{t}$ jet production.
University of Lisbon1, University of Cambridge2, Texas A&M University3, Florida State University4, Johns Hopkins University5, Argonne National Laboratory6, University of Wisconsin-Madison7, Lawrence Berkeley National Laboratory8, University of Vienna9, Stanford University10, Michigan State University11, Royal Holloway, University of London12, Moscow State University13, Fermilab14, Chonbuk National University15, CERN16, University of Freiburg17, Pontifical Catholic University of Chile18, University of Paris19, University of Delhi20, Austrian Academy of Sciences21, National Autonomous University of Mexico22, University of Würzburg23, University of Zurich24, Max Planck Society25, Indian Institute of Science26, Aristotle University of Thessaloniki27, University of Barcelona28, University of California, Davis29, University of Tokushima30, University of California, Santa Cruz31, University of Science and Technology of China32, Tsinghua University33, Uppsala University34, Tokyo Gakugei University35, Spanish National Research Council36, National Taiwan University37, University of Liverpool38, University of Warsaw39, University of Michigan40, Seoul National University41, Yonsei University42, University of Southampton43, University of Bonn44, University of Montpellier45, RWTH Aachen University46, Laboratoire d'Annecy-le-Vieux de physique des particules47, University of Pennsylvania48, Carleton University49, University of Florida50, University of Glasgow51, University of Tokyo52, University of Lyon53, Harish-Chandra Research Institute54, University of Colorado Boulder55, Kyoto University56, University of Minnesota57, University of Rochester58, Durham University59, Tata Institute of Fundamental Research60, Paul Scherrer Institute61, University of Hamburg62, Chung-Ang University63, University of Sheffield64, University of Chicago65, Tohoku University66, Peking University67
TL;DR: In this article, a supersymmetry Parameter Analysis SPA (SPA) scheme is proposed based on a consistent set of conventions and input parameters, which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e(+)e(-) linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles.
Abstract: High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e(+)e(-) linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the desired precision. We take here an initial step of testing the SPA scheme by applying the techniques involved to a specific supersymmetry reference point.
TL;DR: For subsets A of the finite field Fp, p prime, a lower bound of ∆ x 1,...,xk∈A exp(2πix1... xkξ/p) where A ⊂ Fp was shown in this article.
Abstract: Our first result is a ‘sum-product’ theorem for subsets A of the finite field Fp, p prime, providing a lower bound on max(|A + A|, |A · A|). The second and main result provides new bounds on exponential sums ∑ x1,...,xk∈A exp(2πix1 . . . xkξ/p), where A ⊂ Fp.
TL;DR: A direct competitive enzyme-linked immunosorbent assay (ELISA) based on a monoclonal antibody has been developed and optimized for detection of aflatoxin B1 (AFB1), and an ELISA kit has been designed that was highly specific, sensitive, rapid, simple, and suitable for a Flatoxin monitoring.
Abstract: A direct competitive enzyme-linked immunosorbent assay (ELISA) based on a monoclonal antibody has been developed and optimized for detection of aflatoxin B1 (AFB1), and an ELISA kit has been designed. This immunoassay was highly specific, sensitive, rapid, simple, and suitable for aflatoxin monitoring. AFB1 concentrations determinable by ELISA ranged from 0.1 to 10 microg L(-1). The IC50 value was 0.62 microg L(-1). Recovery from spiked rice samples averaged between 94 and 113%. The effect of different reagents on the stability of HRP-AFB1 conjugate solution was studied. The performance of a stabilized enzyme tracer in ELISA was determined and compared with that of a freshly prepared control solution of HRP-AFB(1) conjugate. The results showed that stabilizing media containing 0.02% BSA, 0.1% Kathon CG, and 0.05 mol L(-1) calcium chloride in 0.05 mol L(-1) Tris-HCl buffer (pH 7.2) maintained the activity of HRP-AFB1 at a dilution of 1:1000 for a period of at least 12 months at room temperature whereas the reference conjugate solution without the additives lost its activity within a few days. Several additives were tested for their stabilizing effect on a monoclonal antibody (MAb) immobilized on the surface of polystyrene microtitre plates. It was shown that immobilized MAb, treated with post-coating solutions containing PVA, BSA, and combinations of these substances with trehalose, retained its activity for at least 4 months at 4 degrees C, whereas the untreated MAb-coated plate lost its activity within 2 days.
TL;DR: In this article, high-statistics cross sections for the reactions {gamma}+p{yields}K{sup +}+{lambda} and {Gamma} +p{ yieldss} K{sup+} +{sigma}{sup 0} have been measured using CLAS at Jefferson Lab for center-of-mass energies W between 1.6 and 2.53 GeV, and for -0.85
Abstract: High-statistics cross sections for the reactions {gamma}+p{yields}K{sup +}+{lambda} and {gamma}+p{yields}K{sup +}+{sigma}{sup 0} have been measured using CLAS at Jefferson Lab for center-of-mass energies W between 1.6 and 2.53 GeV, and for -0.85
TL;DR: The review summarizes the results on engineering of bacterial and yeast FDHs aimed at improving their chemical and thermal stability, catalytic activity, switch in coenzyme specificity from NAD+ to NADP+ and overexpression in Escherichia coli cells.
TL;DR: In this paper, the absorptive part of the massless correlator of two quark scalar currents in five loops was computed for the first time, and the decay rate of the standard model Higgs boson into quarks, as well as the constraints on the strange quark mass following from QCD sum rules were considered.
Abstract: We compute, for the first time, the absorptive part of the massless correlator of two quark scalar currents in five loops. As physical applications, we consider the [symbol: see text](alpha(s)4) corrections to the decay rate of the standard model Higgs boson into quarks, as well as the constraints on the strange quark mass following from QCD sum rules.
TL;DR: The ratios of inclusive electron scattering cross sections of 4He, 12C, and 56Fe to 3He have been measured and the first measurement of 3-nucleon SRC probabilities in nuclei is measured.
Abstract: The ratios of inclusive electron scattering cross sections of {sup 4}He, {sup 12}C, and {sup 56}Fe to {sup 3}He have been measured at 1 1.4 GeV{sup 2}, the ratios exhibit two separate plateaus, at 1.5 2.25. This pattern is predicted by models that include 2- and 3-nucleon short-range correlations (SRC). Relative to A=3, the per-nucleon probabilities of 3-nucleon SRC are 2.3, 3.1, and 4.4 times larger for A=4, 12, and 56. This is the first measurement of 3-nucleon SRC probabilities in nuclei.
TL;DR: A gene mutation in families who show an inherited form of hair loss and a hair growth defect is identified, suggesting that lipase H participates in hair growth and development.
Abstract: The molecular mechanisms controlling human hair growth and scalp hair loss are poorly understood. By screening about 350,000 individuals in two populations from the Volga-Ural region of Russia, we identified a gene mutation in families who show an inherited form of hair loss and a hair growth defect. Affected individuals were homozygous for a deletion in the LIPH gene on chromosome 3q27, caused by short interspersed nuclear element–retrotransposon–mediated recombination. The LIPH gene is expressed in hair follicles and encodes a phospholipase called lipase H (alternatively known as membrane-associated phosphatidic acid–selective phospholipase A1α), an enzyme that regulates the production of bioactive lipids. These results suggest that lipase H participates in hair growth and development.