Motilal Nehru National Institute of Technology Allahabad

About: Motilal Nehru National Institute of Technology Allahabad is a education organization based out in Allahabad, Uttar Pradesh, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 2475 authors who have published 5067 publications receiving 61891 citations. The organization is also known as: NIT Allahabad & Motilal Nehru Regional Engineering College.

Digital supply chain management: An Overview

Abstract: Many global supply chains are unequipped to cope with the world we are entering. For that reason, supply chain managers need to shift their attention from cutting costs to enabling new processes, and make corporations more connected and agile to create value across the enterprise. New digital technologies that are emerging everyday are on their way to disrupt nearly all the areas of traditional business processes. The key business priority of almost every industry will find itself in the centre of this upcoming digital era. The process of digitization affects almost everything in today's organizations, including supply chain management and puts huge pressure on organizations to change. Hence it is crucial for managers to understand the implication of digitization on their organization and employees. Current scenario emphasises on the importance of management of people and organization issues in digital transformations. The effect of digitization includes varied impacts on economy as a whole; create tremendous opportunities and challenges for businesses. In the current world of globalization digitization is not a choice but an imperative for all businesses across all industries. Manufacturing processes and work, business model, products and services are the main targets of digitization. The digital transformation enablers and framework discussed in this study-comprised of six techniques of Big data, Cloud services, Unique identification and display innovation, Robotics, Sensors and geolocation, and nanotech and 3D printing-can serve as enablers of digitization.

In situ grafted nanostructured ZnO/carboxymethyl cellulose nanocomposites for efficient delivery of curcumin to cancer

Abstract: In this present manuscript, zinc oxide (ZnO) nanoparticles embedded carboxymethyl cellulose (CMC) bionanocomposite were prepared by in situ grafting and the hydrophobic anticancer drug curcumin (Cur) was loaded into it. Structural, morphological, and physiochemical behavior of prepared curcumin-loaded CMC/ZnO nanocomposites (NCs) were characterized by FTIR, XRD, SEM, TEM, TGA, and DTA. The drug entrapment efficiency was evaluated and the in vitro efficacy as anticancer drug delivery vehicle was analyzed. The potential toxicity of curcumin-loaded ZnO/CMC NCs (Cur/ZnO/CMC NCs) was studied by using L929 and MA104 cell lines via MTT assay. The cellular uptake study of Cur/ZnO/CMC NCs by normal (L929) and cancer (MA104) cells carried out by using ethanol extraction and by FACS analysis has been reported. The results of this investigation demonstrate that the nanomatrix synthesized can effectively deliver the anticancer drug curcumin, and hence appears to be a promising nanoformulation for anticancer therapy and other biomedical applications.