Oklahoma State University–Stillwater

About: Oklahoma State University–Stillwater is a education organization based out in Stillwater, Oklahoma, United States. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 18267 authors who have published 36743 publications receiving 1107500 citations. The organization is also known as: Oklahoma State University & OKState.

Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis.

Abstract: Leptin, a recently-discovered hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety. Although noninsulin-dependent diabetics are insulin-resistant and have greater levels of leptin than normal subjects, little evidence existed previously to support the notion that leptin can influence insulin action, particularly in the ovary. Therefore, we tested the hypothesis that leptin signals metabolic information to the reproductive system by directly affecting insulin-induced thecal cell function. Thecal cells from bovine ovarian follicles were cultured for 2 days in the presence of 10% fetal calf serum, and then cultured for an additional 2 days in serum-free medium with added hormones. Doses of 10 to 300 ng/ml of leptin increased (p 0.10) on thecal cell viability. Specific high-affinity, low-capacity binding of 125I-leptin was also demonstrable in thecal cells. Furthermore, leptin did not compete for [125I]insulin binding to thecal cells, whereas unlabeled insulin did. In conclusion, leptin can directly attenuate insulin-induced steroidogenesis of thecal cells while stimulating proliferation of the same cell type. This inhibitory effect of leptin on steroidogenesis does not appear to be mediated through inhibiting binding of insulin to its receptor but rather appears to be mediated through leptin binding to its own receptor. These results provide evidence for a role of leptin as a metabolic signal to the reproductive system via direct action in the ovary.

Search for Heavy Higgs Bosons Decaying into Two Tau Leptons with the ATLAS Detector Using pp Collisions at s =13 TeV

Abstract: A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb^{-1} of proton-proton collisions at sqrt[s]=13 TeV recorded with the ATLAS detector. The search for heavy resonances is performed over the mass range 0.2-2.5 TeV for the τ^{+}τ^{-} decay with at least one τ-lepton decaying into final states with hadrons. The data are in good agreement with the background prediction of the standard model. In the M_{h}^{125} scenario of the minimal supersymmetric standard model, values of tanβ>8 and tanβ>21 are excluded at the 95% confidence level for neutral Higgs boson masses of 1.0 and 1.5 TeV, respectively, where tanβ is the ratio of the vacuum expectation values of the two Higgs doublets.

Working Memory Deficits and Social Problems in Children with ADHD

Abstract: Social problems are a prevalent feature of ADHD and reflect a major source of functional impairment for these children. The current study examined the impact of working memory deficits on parent- and teacher-reported social problems in a sample of children with ADHD and typically developing boys (N = 39). Bootstrapped, bias-corrected mediation analyses revealed that the impact of working memory deficits on social problems is primarily indirect. That is, impaired social interactions in children with ADHD reflect, to a significant extent, the behavioral outcome of being unable to maintain a focus of attention on information within working memory while simultaneously dividing attention among multiple, on-going events and social cues occurring within the environment. Central executive deficits impacted social problems through both inattentive and impulsive-hyperactive symptoms, whereas the subsidiary phonological and visuospatial storage/rehearsal systems demonstrated a more limited yet distinct relationship with children’s social problems.