Institution
Radboud University Nijmegen
Education•Nijmegen, Gelderland, Netherlands•
About: Radboud University Nijmegen is a education organization based out in Nijmegen, Gelderland, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 35417 authors who have published 83035 publications receiving 3285064 citations. The organization is also known as: Catholic University of Nijmegen & Radboud University.
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TL;DR: A disease activity score (DAS) is a continuous measure consisting of the variables Ritchie articular index, number of swollen joints, erythrocyte sedimentation rate and general health measured on a visual analog scale.
Abstract: In a prospective study of up to 3 years' duration of 113 patients with early rheumatoid arthritis a disease activity score (DAS) was developed based on the clinical judgment of 6 rheumatologists The patients were divided in groups with high and low disease activity according to explicit rules By various statistical methods, including discriminant analysis and multiple regression analysis, a DAS could be defined This DAS is a continuous measure consisting of the variables Ritchie articular index, number of swollen joints, erythrocyte sedimentation rate and general health measured on a visual analog scale
721 citations
TL;DR: In this paper, the authors conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts.
Abstract: The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.
721 citations
Paul Sabatier University1, Memorial Sloan Kettering Cancer Center2, university of lille3, University of Paris-Sud4, Aix-Marseille University5, Radboud University Nijmegen6, Stanford University7, Ben-Gurion University of the Negev8, University of Bern9, University of Colorado Boulder10, The Royal Marsden NHS Foundation Trust11, University of California, Irvine12, University Hospital of Basel13, University of Turin14, University of Zurich15, University of Grenoble16, University of Duisburg-Essen17
TL;DR: In certain subgroups, PFS was positively associated with PD-L1 expression (KRAS, EGFR) and with smoking status (BRAF, HER2) and the lack of response in the ALK group was notable.
719 citations
TL;DR: Human regulatory T cells can differentiate into IL-17-producing cells, when stimulated by allogeneic antigen-presenting cells, especially monocytes, in the presence of rhIL-2/rhIL-15, and data suggest that epigenetic modification underlies the phenomenon of Treg plasticity here described.
719 citations
Goethe University Frankfurt1, University of Maryland, College Park2, University of Guelph3, Duke University4, Radboud University Nijmegen5, Swedish University of Agricultural Sciences6, Federal University of Mato Grosso do Sul7, University of Alberta8, Royal Veterinary College9, Wildlife Conservation Society10, Mississippi State University11, Sao Paulo State University12, Michigan Department of Natural Resources13, University of California, Davis14, Aarhus University15, Max Planck Society16, University of Potsdam17, Middle Tennessee State University18, Mammal Research Institute19, Edmund Mach Foundation20, Harvard University21, Smithsonian Conservation Biology Institute22, University of Évora23, University of Montpellier24, Parks Victoria25, Monash University26, Ohio State University27, Fiji National University28, University of Massachusetts Amherst29, United States Geological Survey30, Save the Elephants31, University of Oxford32, German Primate Center33, Technische Universität München34, Institute of Ecosystem Studies35, University of British Columbia36, University of Zurich37, University of Wyoming38, University of Washington39, University of Montana40, Bavarian Forest National Park41, University of Freiburg42, University of Toulouse43, University of Veterinary Medicine Vienna44, University College Cork45, North Carolina State University46, North Carolina Museum of Natural Sciences47, Karatina University48, University of Lethbridge49, Lamont–Doherty Earth Observatory50, University of Valencia51, Stony Brook University52, International Union for Conservation of Nature and Natural Resources53, University of Alicante54, Empresa Brasileira de Pesquisa Agropecuária55, University of Glasgow56, New York University57, University of Oslo58, Hebrew University of Jerusalem59, Norwegian University of Science and Technology60, Field Museum of Natural History61, University of Bayreuth62, University of Grenoble63, University of New South Wales64, Pennsylvania Game Commission65, Princeton University66, University of Konstanz67, University of Haifa68, Polish Academy of Sciences69, University of Porto70, Instituto Superior de Agronomia71, University of Lisbon72, University of California, Santa Cruz73, University of Pretoria74, Colorado State University75
TL;DR: Using a unique GPS-tracking database of 803 individuals across 57 species, it is found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in area with a low human footprint.
Abstract: Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.
719 citations
Authors
Showing all 35749 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Charles A. Dinarello | 190 | 1058 | 139668 |
| Richard H. Friend | 169 | 1182 | 140032 |
| Yang Gao | 168 | 2047 | 146301 |
| Ian J. Deary | 166 | 1795 | 114161 |
| David T. Felson | 153 | 861 | 133514 |
| Margaret A. Pericak-Vance | 149 | 826 | 118672 |
| Fernando Rivadeneira | 146 | 628 | 86582 |
| Shah Ebrahim | 146 | 733 | 96807 |
| Mihai G. Netea | 142 | 1170 | 86908 |
| Mingshui Chen | 141 | 1543 | 125369 |
| George Alverson | 140 | 1653 | 105074 |
| Barry Blumenfeld | 140 | 1909 | 105694 |
| Harvey B Newman | 139 | 1594 | 88308 |
| Tariq Aziz | 138 | 1646 | 96586 |
| Stylianos E. Antonarakis | 138 | 746 | 93605 |