Romanian Academy

About: Romanian Academy is a archive organization based out in Bucharest, Romania. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 3662 authors who have published 10491 publications receiving 146447 citations. The organization is also known as: Academia Română & Societatea Literară Română.

Silica-Coated Magnetic Nanocomposites for Pb2+ Removal from Aqueous Solution

Abstract: Magnetic iron oxide-silica shell nanocomposites with different iron oxide/silica ratio were synthesized and structurally characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), small-angle neutron scattering, magnetic and N2-sorption studies. The composite that resulted with the best properties in terms of contact surface area and saturation of magnetization was selected for Pb2+ adsorption studies from aqueous media. The material presented good absorption capacity (maximum adsorption capacity 14.9 mg·g−1) comparable with similar materials presented in literature. Its chemico-physical stability and adsorption capacity recommend the nanocomposite as a cheap adsorbent material for lead.

The EUTOS long-term survival (ELTS) score is superior to the Sokal score for predicting survival in chronic myeloid leukemia

Abstract: Prognostic scores support clinicians in selecting risk-adjusted treatments and in comparatively assessing different results For patients with chronic-phase chronic myeloid leukemia (CML), four baseline prognostic scores are commonly used Our aim was to compare the prognostic performance of the scores and to arrive at an evidence-based score recommendation In 2949 patients not involved in any score development, higher hazard ratios and concordance indices in any comparison demonstrated the best discrimination of long-term survival with the ELTS score In a second step, of 5154 patients analyzed to investigate risk group classification differences, 23% (n = 1197) were allocated to high-risk by the Sokal score Of the 1197 Sokal high-risk patients, 56% were non-high-risk according to the ELTS score and had a significantly more favorable long-term survival prognosis than the 526 high-risk patients according to both scores The Sokal score identified too many patients as high-risk and relatively few (40%) as low-risk (versus 60% with the ELTS score) Inappropriate risk classification jeopardizes optimal treatment selection The ELTS score outperformed the Sokal score, the Euro, and the EUTOS score regarding risk group discrimination The recent recommendation of the European LeukemiaNet for preferred use of the ELTS score was supported with significant statistical evidence

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants.

Abstract: Oxygen-free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS), are known by their “double-sided” nature in biological systems. The beneficial effects of ROS involve physiological roles as weapons in the arsenal of the immune system (destroying bacteria within phagocytic cells) and role in programmed cell death (apoptosis). On the other hand, the redox imbalance in favor of the prooxidants results in an overproduction of the ROS/RNS leading to oxidative stress. This imbalance can, therefore, be related to oncogenic stimulation. High levels of ROS disrupt cellular processes by nonspecifically attacking proteins, lipids, and DNA. It appears that DNA damage is the key player in cancer initiation and the formation of 8-OH-G, a potential biomarker for carcinogenesis. The harmful effect of ROS is neutralized by an antioxidant protection treatment as they convert ROS into less reactive species. However, contradictory epidemiological results show that supplementation above physiological doses recommended for antioxidants and taken over a long period can lead to harmful effects and even increase the risk of cancer. Thus, we are describing here some of the latest updates on the involvement of oxidative stress in cancer pathology and a double view on the role of the antioxidants in this context and how this could be relevant in the management and pathology of cancer.

Syntheses, Spectroscopic and AFM Characterization of Some Manganese Porphyrins and Their Hybrid Silica Nanomaterials

Abstract: The present work is concerned with the manganese complexes of 5,10,15,20-tetraphenylporphyrin and of 5,10,15,20-tetra(3-hydroxyphenyl)porphyrin, which were prepared by metallation of the corresponding porphyrin ligands, and the study of their spectroscopic and photophysical behavior under strongly acidic and alkaline conditions. The second objective was to obtain and study some new hybrid materials, with special optoelectronic and surface properties, by impregnation of silica gels obtained by one step acid and by two steps acid-base catalysis with these Mn-porphyrins. The resulting nanomaterials exhibited interesting bathochromic and hyperchromic effects of their second band in the emission spectra in comparison with the Mn-porphyrins and also they have distinct orientation of the aggregates on surfaces, as shown by AFM images, making them useful for applications in medicine, formulation of sensors and for environmental-friendly catalysts for photodegradation of organic compounds.